Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma

We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, sugg...

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Autores principales: Lemaire, F, Millon, R, Muller, D, Rabouel, Y, Bracco, L, Abecassis, J, Wasylyk, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409811/
https://www.ncbi.nlm.nih.gov/pubmed/15213722
http://dx.doi.org/10.1038/sj.bjc.6601952
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author Lemaire, F
Millon, R
Muller, D
Rabouel, Y
Bracco, L
Abecassis, J
Wasylyk, B
author_facet Lemaire, F
Millon, R
Muller, D
Rabouel, Y
Bracco, L
Abecassis, J
Wasylyk, B
author_sort Lemaire, F
collection PubMed
description We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC).
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spelling pubmed-24098112009-09-10 Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma Lemaire, F Millon, R Muller, D Rabouel, Y Bracco, L Abecassis, J Wasylyk, B Br J Cancer Molecular and Cellular Pathology We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC). Nature Publishing Group 2004-07-19 2004-06-22 /pmc/articles/PMC2409811/ /pubmed/15213722 http://dx.doi.org/10.1038/sj.bjc.6601952 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Lemaire, F
Millon, R
Muller, D
Rabouel, Y
Bracco, L
Abecassis, J
Wasylyk, B
Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
title Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
title_full Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
title_fullStr Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
title_full_unstemmed Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
title_short Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
title_sort loss of hop tumour suppressor expression in head and neck squamous cell carcinoma
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409811/
https://www.ncbi.nlm.nih.gov/pubmed/15213722
http://dx.doi.org/10.1038/sj.bjc.6601952
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