The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website...

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Autores principales: Bamford, S, Dawson, E, Forbes, S, Clements, J, Pettett, R, Dogan, A, Flanagan, A, Teague, J, Futreal, P A, Stratton, M R, Wooster, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409828/
https://www.ncbi.nlm.nih.gov/pubmed/15188009
http://dx.doi.org/10.1038/sj.bjc.6601894
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author Bamford, S
Dawson, E
Forbes, S
Clements, J
Pettett, R
Dogan, A
Flanagan, A
Teague, J
Futreal, P A
Stratton, M R
Wooster, R
author_facet Bamford, S
Dawson, E
Forbes, S
Clements, J
Pettett, R
Dogan, A
Flanagan, A
Teague, J
Futreal, P A
Stratton, M R
Wooster, R
author_sort Bamford, S
collection PubMed
description The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.
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spelling pubmed-24098282009-09-10 The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website Bamford, S Dawson, E Forbes, S Clements, J Pettett, R Dogan, A Flanagan, A Teague, J Futreal, P A Stratton, M R Wooster, R Br J Cancer Genetics and Genomics The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website. Nature Publishing Group 2004-07-19 2004-06-08 /pmc/articles/PMC2409828/ /pubmed/15188009 http://dx.doi.org/10.1038/sj.bjc.6601894 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Bamford, S
Dawson, E
Forbes, S
Clements, J
Pettett, R
Dogan, A
Flanagan, A
Teague, J
Futreal, P A
Stratton, M R
Wooster, R
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
title The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
title_full The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
title_fullStr The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
title_full_unstemmed The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
title_short The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
title_sort cosmic (catalogue of somatic mutations in cancer) database and website
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409828/
https://www.ncbi.nlm.nih.gov/pubmed/15188009
http://dx.doi.org/10.1038/sj.bjc.6601894
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