Nuclear survivin as a biomarker for non-small-cell lung cancer

Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9,...

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Detalles Bibliográficos
Autores principales: Lu, B, Gonzalez, A, Massion, P P, Shyr, Y, Shaktour, B, Carbone, D P, Hallahan, D E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409840/
https://www.ncbi.nlm.nih.gov/pubmed/15266313
http://dx.doi.org/10.1038/sj.bjc.6602027
Descripción
Sumario:Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.

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