Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer

This retrospective study aimed at evaluating the prognostic impact of high serum levels of either the HER-2 extracellular domain (ECD) or the epidermal growth factor receptor (EGFR) ECD measured using two specific ELISAs in 221 patients with non-small-cell lung cancer (NSCLC) receiving conventional...

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Autores principales: Jacot, W, Pujol, J-L, Boher, J-M, Lamy, P-J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409859/
https://www.ncbi.nlm.nih.gov/pubmed/15226769
http://dx.doi.org/10.1038/sj.bjc.6601987
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author Jacot, W
Pujol, J-L
Boher, J-M
Lamy, P-J
author_facet Jacot, W
Pujol, J-L
Boher, J-M
Lamy, P-J
author_sort Jacot, W
collection PubMed
description This retrospective study aimed at evaluating the prognostic impact of high serum levels of either the HER-2 extracellular domain (ECD) or the epidermal growth factor receptor (EGFR) ECD measured using two specific ELISAs in 221 patients with non-small-cell lung cancer (NSCLC) receiving conventional therapy and 41 nonmalignant pulmonary diseases patients. It was not possible to discriminate between lung cancer and benign lung disease owing to the lack of sensitivity–specificity relationship of HER-2 and EGFR ECD levels. Neither HER-2 nor EGFR ECD specific levels were associated with a particular prognosis of NSCLC patients receiving conventional therapy.
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spelling pubmed-24098592009-09-10 Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer Jacot, W Pujol, J-L Boher, J-M Lamy, P-J Br J Cancer Short Communication This retrospective study aimed at evaluating the prognostic impact of high serum levels of either the HER-2 extracellular domain (ECD) or the epidermal growth factor receptor (EGFR) ECD measured using two specific ELISAs in 221 patients with non-small-cell lung cancer (NSCLC) receiving conventional therapy and 41 nonmalignant pulmonary diseases patients. It was not possible to discriminate between lung cancer and benign lung disease owing to the lack of sensitivity–specificity relationship of HER-2 and EGFR ECD levels. Neither HER-2 nor EGFR ECD specific levels were associated with a particular prognosis of NSCLC patients receiving conventional therapy. Nature Publishing Group 2004-08-02 2004-06-29 /pmc/articles/PMC2409859/ /pubmed/15226769 http://dx.doi.org/10.1038/sj.bjc.6601987 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Jacot, W
Pujol, J-L
Boher, J-M
Lamy, P-J
Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer
title Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer
title_full Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer
title_fullStr Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer
title_full_unstemmed Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer
title_short Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer
title_sort serum egf-receptor and her-2 extracellular domains and prognosis of non-small-cell lung cancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409859/
https://www.ncbi.nlm.nih.gov/pubmed/15226769
http://dx.doi.org/10.1038/sj.bjc.6601987
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