Human herpes virus 6 or Epstein–Barr virus were not detected in Guthrie cards from children who later developed leukaemia

To investigate if children who later developed acute lymphoblastic leukaemia (ALL) were prenatally infected with HHV-6 and/or EBV, Guthrie cards taken at birth were analysed by PCR. Guthrie cards from 54 patients with ALL and 47 healthy controls matched for age and birth place were tested negative f...

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Autores principales: Bogdanovic, G, Jernberg, Å G, Priftakis, P, Grillner, L, Gustafsson, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409878/
https://www.ncbi.nlm.nih.gov/pubmed/15292925
http://dx.doi.org/10.1038/sj.bjc.6602099
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author Bogdanovic, G
Jernberg, Å G
Priftakis, P
Grillner, L
Gustafsson, B
author_facet Bogdanovic, G
Jernberg, Å G
Priftakis, P
Grillner, L
Gustafsson, B
author_sort Bogdanovic, G
collection PubMed
description To investigate if children who later developed acute lymphoblastic leukaemia (ALL) were prenatally infected with HHV-6 and/or EBV, Guthrie cards taken at birth were analysed by PCR. Guthrie cards from 54 patients with ALL and 47 healthy controls matched for age and birth place were tested negative for both HHV-6 and EBV DNA. All samples contained amplifiable DNA when tested by HLA-DQ PCR. Our negative findings suggest that childhood ALL is unlikely to be associated with an in utero infection with EBV or HHV-6.
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spelling pubmed-24098782009-09-10 Human herpes virus 6 or Epstein–Barr virus were not detected in Guthrie cards from children who later developed leukaemia Bogdanovic, G Jernberg, Å G Priftakis, P Grillner, L Gustafsson, B Br J Cancer Epidemiology To investigate if children who later developed acute lymphoblastic leukaemia (ALL) were prenatally infected with HHV-6 and/or EBV, Guthrie cards taken at birth were analysed by PCR. Guthrie cards from 54 patients with ALL and 47 healthy controls matched for age and birth place were tested negative for both HHV-6 and EBV DNA. All samples contained amplifiable DNA when tested by HLA-DQ PCR. Our negative findings suggest that childhood ALL is unlikely to be associated with an in utero infection with EBV or HHV-6. Nature Publishing Group 2004-08-31 2004-08-24 /pmc/articles/PMC2409878/ /pubmed/15292925 http://dx.doi.org/10.1038/sj.bjc.6602099 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Bogdanovic, G
Jernberg, Å G
Priftakis, P
Grillner, L
Gustafsson, B
Human herpes virus 6 or Epstein–Barr virus were not detected in Guthrie cards from children who later developed leukaemia
title Human herpes virus 6 or Epstein–Barr virus were not detected in Guthrie cards from children who later developed leukaemia
title_full Human herpes virus 6 or Epstein–Barr virus were not detected in Guthrie cards from children who later developed leukaemia
title_fullStr Human herpes virus 6 or Epstein–Barr virus were not detected in Guthrie cards from children who later developed leukaemia
title_full_unstemmed Human herpes virus 6 or Epstein–Barr virus were not detected in Guthrie cards from children who later developed leukaemia
title_short Human herpes virus 6 or Epstein–Barr virus were not detected in Guthrie cards from children who later developed leukaemia
title_sort human herpes virus 6 or epstein–barr virus were not detected in guthrie cards from children who later developed leukaemia
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409878/
https://www.ncbi.nlm.nih.gov/pubmed/15292925
http://dx.doi.org/10.1038/sj.bjc.6602099
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