Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene

Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1...

Descripción completa

Detalles Bibliográficos
Autores principales: Berge, G, Øvrebø, S, Eilertsen, E, Haugen, A, Mollerup, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409901/
https://www.ncbi.nlm.nih.gov/pubmed/15316568
http://dx.doi.org/10.1038/sj.bjc.6602125
_version_ 1782155893902671872
author Berge, G
Øvrebø, S
Eilertsen, E
Haugen, A
Mollerup, S
author_facet Berge, G
Øvrebø, S
Eilertsen, E
Haugen, A
Mollerup, S
author_sort Berge, G
collection PubMed
description Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[a]pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs.
format Text
id pubmed-2409901
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-24099012009-09-10 Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene Berge, G Øvrebø, S Eilertsen, E Haugen, A Mollerup, S Br J Cancer Experimental Therapeutics Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[a]pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs. Nature Publishing Group 2004-10-04 2004-08-17 /pmc/articles/PMC2409901/ /pubmed/15316568 http://dx.doi.org/10.1038/sj.bjc.6602125 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Berge, G
Øvrebø, S
Eilertsen, E
Haugen, A
Mollerup, S
Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene
title Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene
title_full Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene
title_fullStr Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene
title_full_unstemmed Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene
title_short Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene
title_sort analysis of resveratrol as a lung cancer chemopreventive agent in a/j mice exposed to benzo[a]pyrene
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409901/
https://www.ncbi.nlm.nih.gov/pubmed/15316568
http://dx.doi.org/10.1038/sj.bjc.6602125
work_keys_str_mv AT bergeg analysisofresveratrolasalungcancerchemopreventiveagentinajmiceexposedtobenzoapyrene
AT øvrebøs analysisofresveratrolasalungcancerchemopreventiveagentinajmiceexposedtobenzoapyrene
AT eilertsene analysisofresveratrolasalungcancerchemopreventiveagentinajmiceexposedtobenzoapyrene
AT haugena analysisofresveratrolasalungcancerchemopreventiveagentinajmiceexposedtobenzoapyrene
AT mollerups analysisofresveratrolasalungcancerchemopreventiveagentinajmiceexposedtobenzoapyrene

Ejemplares similares