Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy

Elderly patients are recommended to have a reduced starting dose (300 mg m(−2) once every 3 weeks) of irinotecan monotherapy. The aims of this analysis are to compare toxicity and survival according to age, performance status (PS), gender and prior radical pelvic radiotherapy (RT). The primary end p...

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Detalles Bibliográficos
Autores principales: Chau, I, Norman, A R, Cunningham, D, Waters, J S, Topham, C, Middleton, G, Hill, M, Ross, P J, Katopodis, R, Stewart, G, Oates, J R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409923/
https://www.ncbi.nlm.nih.gov/pubmed/15365570
http://dx.doi.org/10.1038/sj.bjc.6602169

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