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Phase I dose-escalation trial of irinotecan with continuous infusion 5-FU first line, in metastatic colorectal cancer

This single-centre phase I trial was designed to determine the maximum tolerated dose of irinotecan and the recommended dose to use in combination with a fixed dose of 5-fluorouracil (5-FU) administered as a protracted venous infusion, for the first-line treatment of metastatic colorectal cancer (CR...

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Detalles Bibliográficos
Autores principales:	Saunders, M P, Hogg, M, Carrington, B, Sjursen, A-M, Allen, J, Beech, J, Swindell, R, Valle, J W
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Clinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409945/ https://www.ncbi.nlm.nih.gov/pubmed/15452550 http://dx.doi.org/10.1038/sj.bjc.6602173

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