Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?

To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evi...

Descripción completa

Detalles Bibliográficos
Autores principales: Verburg, F A, Lips, C J M, Lentjes, E G W M, de Klerk, J M H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409974/
https://www.ncbi.nlm.nih.gov/pubmed/15213710
http://dx.doi.org/10.1038/sj.bjc.6601991
_version_ 1782155913781575680
author Verburg, F A
Lips, C J M
Lentjes, E G W M
de Klerk, J M H
author_facet Verburg, F A
Lips, C J M
Lentjes, E G W M
de Klerk, J M H
author_sort Verburg, F A
collection PubMed
description To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT–PCR measurements during follow-up still warrants further research.
format Text
id pubmed-2409974
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-24099742009-09-10 Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it? Verburg, F A Lips, C J M Lentjes, E G W M de Klerk, J M H Br J Cancer Minireview To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT–PCR measurements during follow-up still warrants further research. Nature Publishing Group 2004-07-19 2004-06-22 /pmc/articles/PMC2409974/ /pubmed/15213710 http://dx.doi.org/10.1038/sj.bjc.6601991 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Verburg, F A
Lips, C J M
Lentjes, E G W M
de Klerk, J M H
Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?
title Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?
title_full Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?
title_fullStr Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?
title_full_unstemmed Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?
title_short Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?
title_sort detection of circulating tg-mrna in the follow-up of papillary and follicular thyroid cancer: how useful is it?
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409974/
https://www.ncbi.nlm.nih.gov/pubmed/15213710
http://dx.doi.org/10.1038/sj.bjc.6601991
work_keys_str_mv AT verburgfa detectionofcirculatingtgmrnainthefollowupofpapillaryandfollicularthyroidcancerhowusefulisit
AT lipscjm detectionofcirculatingtgmrnainthefollowupofpapillaryandfollicularthyroidcancerhowusefulisit
AT lentjesegwm detectionofcirculatingtgmrnainthefollowupofpapillaryandfollicularthyroidcancerhowusefulisit
AT deklerkjmh detectionofcirculatingtgmrnainthefollowupofpapillaryandfollicularthyroidcancerhowusefulisit

Ejemplares similares