Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice

The fragile histidine triad (FHIT) gene is frequently inactivated in various types of tumours. However, the system-wide pathology caused by FHIT inactivation has not been examined in detail. Here we demonstrate that Fhit gene knockout mice develop tumours in the lymphoid tissue, liver, uterus, testi...

Descripción completa

Detalles Bibliográficos
Autores principales: Fujishita, T, Doi, Y, Sonoshita, M, Hiai, H, Oshima, M, Huebner, K, Croce, C M, Taketo, M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410018/
https://www.ncbi.nlm.nih.gov/pubmed/15467769
http://dx.doi.org/10.1038/sj.bjc.6602182
Descripción
Sumario:The fragile histidine triad (FHIT) gene is frequently inactivated in various types of tumours. However, the system-wide pathology caused by FHIT inactivation has not been examined in detail. Here we demonstrate that Fhit gene knockout mice develop tumours in the lymphoid tissue, liver, uterus, testis, forestomach and small intestine, together with structural abnormalities in the small intestinal mucosa. These results suggest that Fhit plays important roles in systemic tumour suppression and in the integrity of mucosal structure of the intestines.

Ejemplares similares