Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice

The fragile histidine triad (FHIT) gene is frequently inactivated in various types of tumours. However, the system-wide pathology caused by FHIT inactivation has not been examined in detail. Here we demonstrate that Fhit gene knockout mice develop tumours in the lymphoid tissue, liver, uterus, testi...

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Autores principales: Fujishita, T, Doi, Y, Sonoshita, M, Hiai, H, Oshima, M, Huebner, K, Croce, C M, Taketo, M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410018/
https://www.ncbi.nlm.nih.gov/pubmed/15467769
http://dx.doi.org/10.1038/sj.bjc.6602182
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author Fujishita, T
Doi, Y
Sonoshita, M
Hiai, H
Oshima, M
Huebner, K
Croce, C M
Taketo, M M
author_facet Fujishita, T
Doi, Y
Sonoshita, M
Hiai, H
Oshima, M
Huebner, K
Croce, C M
Taketo, M M
author_sort Fujishita, T
collection PubMed
description The fragile histidine triad (FHIT) gene is frequently inactivated in various types of tumours. However, the system-wide pathology caused by FHIT inactivation has not been examined in detail. Here we demonstrate that Fhit gene knockout mice develop tumours in the lymphoid tissue, liver, uterus, testis, forestomach and small intestine, together with structural abnormalities in the small intestinal mucosa. These results suggest that Fhit plays important roles in systemic tumour suppression and in the integrity of mucosal structure of the intestines.
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spelling pubmed-24100182009-09-10 Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice Fujishita, T Doi, Y Sonoshita, M Hiai, H Oshima, M Huebner, K Croce, C M Taketo, M M Br J Cancer Short Communication The fragile histidine triad (FHIT) gene is frequently inactivated in various types of tumours. However, the system-wide pathology caused by FHIT inactivation has not been examined in detail. Here we demonstrate that Fhit gene knockout mice develop tumours in the lymphoid tissue, liver, uterus, testis, forestomach and small intestine, together with structural abnormalities in the small intestinal mucosa. These results suggest that Fhit plays important roles in systemic tumour suppression and in the integrity of mucosal structure of the intestines. Nature Publishing Group 2004-10-18 2004-10-05 /pmc/articles/PMC2410018/ /pubmed/15467769 http://dx.doi.org/10.1038/sj.bjc.6602182 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Fujishita, T
Doi, Y
Sonoshita, M
Hiai, H
Oshima, M
Huebner, K
Croce, C M
Taketo, M M
Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
title Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
title_full Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
title_fullStr Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
title_full_unstemmed Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
title_short Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
title_sort development of spontaneous tumours and intestinal lesions in fhit gene knockout mice
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410018/
https://www.ncbi.nlm.nih.gov/pubmed/15467769
http://dx.doi.org/10.1038/sj.bjc.6602182
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