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Lower breast cancer survival in mothers of children with a malignancy: a national study
As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961–1999 in Sweden, having a child with childhood cancer (⩽20 years of age; n=254) and with that of other women (n=74 781). Those hav...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410117/ https://www.ncbi.nlm.nih.gov/pubmed/18458676 http://dx.doi.org/10.1038/sj.bjc.6604350 |
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author | Olsson, H Magnusson, S Bladström, A |
author_facet | Olsson, H Magnusson, S Bladström, A |
author_sort | Olsson, H |
collection | PubMed |
description | As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961–1999 in Sweden, having a child with childhood cancer (⩽20 years of age; n=254) and with that of other women (n=74 781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02–1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li–Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival. |
format | Text |
id | pubmed-2410117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-24101172009-09-10 Lower breast cancer survival in mothers of children with a malignancy: a national study Olsson, H Magnusson, S Bladström, A Br J Cancer Epidemiology As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961–1999 in Sweden, having a child with childhood cancer (⩽20 years of age; n=254) and with that of other women (n=74 781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02–1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li–Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival. Nature Publishing Group 2008-06-03 2008-05-06 /pmc/articles/PMC2410117/ /pubmed/18458676 http://dx.doi.org/10.1038/sj.bjc.6604350 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Olsson, H Magnusson, S Bladström, A Lower breast cancer survival in mothers of children with a malignancy: a national study |
title | Lower breast cancer survival in mothers of children with a malignancy: a national study |
title_full | Lower breast cancer survival in mothers of children with a malignancy: a national study |
title_fullStr | Lower breast cancer survival in mothers of children with a malignancy: a national study |
title_full_unstemmed | Lower breast cancer survival in mothers of children with a malignancy: a national study |
title_short | Lower breast cancer survival in mothers of children with a malignancy: a national study |
title_sort | lower breast cancer survival in mothers of children with a malignancy: a national study |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410117/ https://www.ncbi.nlm.nih.gov/pubmed/18458676 http://dx.doi.org/10.1038/sj.bjc.6604350 |
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