MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not

The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(−1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP...

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Detalles Bibliográficos
Autores principales: Langers, A M J, Sier, C F M, Hawinkels, L J A C, Kubben, F J G M, van Duijn, W, van der Reijden, J J, Lamers, C B H W, Hommes, D W, Verspaget, H W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410128/
https://www.ncbi.nlm.nih.gov/pubmed/18506186
http://dx.doi.org/10.1038/sj.bjc.6604380
Descripción
Sumario:The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(−1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(−1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes.

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