MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not

The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(−1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP...

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Autores principales: Langers, A M J, Sier, C F M, Hawinkels, L J A C, Kubben, F J G M, van Duijn, W, van der Reijden, J J, Lamers, C B H W, Hommes, D W, Verspaget, H W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410128/
https://www.ncbi.nlm.nih.gov/pubmed/18506186
http://dx.doi.org/10.1038/sj.bjc.6604380
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author Langers, A M J
Sier, C F M
Hawinkels, L J A C
Kubben, F J G M
van Duijn, W
van der Reijden, J J
Lamers, C B H W
Hommes, D W
Verspaget, H W
author_facet Langers, A M J
Sier, C F M
Hawinkels, L J A C
Kubben, F J G M
van Duijn, W
van der Reijden, J J
Lamers, C B H W
Hommes, D W
Verspaget, H W
author_sort Langers, A M J
collection PubMed
description The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(−1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(−1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes.
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spelling pubmed-24101282009-09-10 MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not Langers, A M J Sier, C F M Hawinkels, L J A C Kubben, F J G M van Duijn, W van der Reijden, J J Lamers, C B H W Hommes, D W Verspaget, H W Br J Cancer Short Communication The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(−1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(−1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes. Nature Publishing Group 2008-06-03 2008-05-27 /pmc/articles/PMC2410128/ /pubmed/18506186 http://dx.doi.org/10.1038/sj.bjc.6604380 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Langers, A M J
Sier, C F M
Hawinkels, L J A C
Kubben, F J G M
van Duijn, W
van der Reijden, J J
Lamers, C B H W
Hommes, D W
Verspaget, H W
MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not
title MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not
title_full MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not
title_fullStr MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not
title_full_unstemmed MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not
title_short MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not
title_sort mmp-2 geno-phenotype is prognostic for colorectal cancer survival, whereas mmp-9 is not
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410128/
https://www.ncbi.nlm.nih.gov/pubmed/18506186
http://dx.doi.org/10.1038/sj.bjc.6604380
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