Integrins: roles in cancer development and as treatment targets

The integrin family of cell adhesion proteins promotes the attachment and migration of cells on the surrounding extracellular matrix (ECM). Through signals transduced upon integrin ligation by ECM proteins or immunoglobulin superfamily molecules, this family of proteins plays key roles in regulating...

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Detalles Bibliográficos
Autores principales: Jin, H, Varner, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410157/
https://www.ncbi.nlm.nih.gov/pubmed/14760364
http://dx.doi.org/10.1038/sj.bjc.6601576
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author Jin, H
Varner, J
author_facet Jin, H
Varner, J
author_sort Jin, H
collection PubMed
description The integrin family of cell adhesion proteins promotes the attachment and migration of cells on the surrounding extracellular matrix (ECM). Through signals transduced upon integrin ligation by ECM proteins or immunoglobulin superfamily molecules, this family of proteins plays key roles in regulating tumour growth and metastasis as well as tumour angiogenesis. Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis. Antagonists of several integrins (α5β1, αvβ3 and αvβ5) are now under evaluation in clinical trials to determine their potential as therapeutics for cancer and other diseases.
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spelling pubmed-24101572009-09-10 Integrins: roles in cancer development and as treatment targets Jin, H Varner, J Br J Cancer Minireview The integrin family of cell adhesion proteins promotes the attachment and migration of cells on the surrounding extracellular matrix (ECM). Through signals transduced upon integrin ligation by ECM proteins or immunoglobulin superfamily molecules, this family of proteins plays key roles in regulating tumour growth and metastasis as well as tumour angiogenesis. Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis. Antagonists of several integrins (α5β1, αvβ3 and αvβ5) are now under evaluation in clinical trials to determine their potential as therapeutics for cancer and other diseases. Nature Publishing Group 2004-02-09 2004-02-03 /pmc/articles/PMC2410157/ /pubmed/14760364 http://dx.doi.org/10.1038/sj.bjc.6601576 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Jin, H
Varner, J
Integrins: roles in cancer development and as treatment targets
title Integrins: roles in cancer development and as treatment targets
title_full Integrins: roles in cancer development and as treatment targets
title_fullStr Integrins: roles in cancer development and as treatment targets
title_full_unstemmed Integrins: roles in cancer development and as treatment targets
title_short Integrins: roles in cancer development and as treatment targets
title_sort integrins: roles in cancer development and as treatment targets
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410157/
https://www.ncbi.nlm.nih.gov/pubmed/14760364
http://dx.doi.org/10.1038/sj.bjc.6601576
work_keys_str_mv AT jinh integrinsrolesincancerdevelopmentandastreatmenttargets
AT varnerj integrinsrolesincancerdevelopmentandastreatmenttargets

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