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Genetic testing among high-risk individuals in families with hereditary nonpolyposis colorectal cancer

Hereditary nonpolyposis colorectal cancer (HNPCC) is frequently associated with constitutional mutations in a class of genes involved in DNA mismatch repair. We identified 32 kindreds, with germline mutations in one of three genes hMSH2, hMLH1 or hMSH6. In this study, we purposed to evaluate how man...

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Detalles Bibliográficos
Autores principales:	Ponz de Leon, M, Benatti, P, Di Gregorio, C, Pedroni, M, Losi, L, Genuardi, M, Viel, A, Fornasarig, M, Lucci-Cordisco, E, Anti, M, Ponti, G, Borghi, F, Lamberti, I, Roncucci, L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410159/ https://www.ncbi.nlm.nih.gov/pubmed/14970868 http://dx.doi.org/10.1038/sj.bjc.6601529

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