Linking the epigenetic ‘language’ of covalent histone modifications to cancer

Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching imp...

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Detalles Bibliográficos
Autores principales: Hake, S B, Xiao, A, Allis, C D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410168/
https://www.ncbi.nlm.nih.gov/pubmed/14970850
http://dx.doi.org/10.1038/sj.bjc.6601575
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author Hake, S B
Xiao, A
Allis, C D
author_facet Hake, S B
Xiao, A
Allis, C D
author_sort Hake, S B
collection PubMed
description Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human biology and human health. This review focuses on how aberrant covalent histone modifications may contribute to the development of a variety of human cancers, and discusses the recent findings with regard to potential therapies.
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spelling pubmed-24101682009-09-10 Linking the epigenetic ‘language’ of covalent histone modifications to cancer Hake, S B Xiao, A Allis, C D Br J Cancer Review Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human biology and human health. This review focuses on how aberrant covalent histone modifications may contribute to the development of a variety of human cancers, and discusses the recent findings with regard to potential therapies. Nature Publishing Group 2004-02-23 2004-02-17 /pmc/articles/PMC2410168/ /pubmed/14970850 http://dx.doi.org/10.1038/sj.bjc.6601575 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Hake, S B
Xiao, A
Allis, C D
Linking the epigenetic ‘language’ of covalent histone modifications to cancer
title Linking the epigenetic ‘language’ of covalent histone modifications to cancer
title_full Linking the epigenetic ‘language’ of covalent histone modifications to cancer
title_fullStr Linking the epigenetic ‘language’ of covalent histone modifications to cancer
title_full_unstemmed Linking the epigenetic ‘language’ of covalent histone modifications to cancer
title_short Linking the epigenetic ‘language’ of covalent histone modifications to cancer
title_sort linking the epigenetic ‘language’ of covalent histone modifications to cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410168/
https://www.ncbi.nlm.nih.gov/pubmed/14970850
http://dx.doi.org/10.1038/sj.bjc.6601575
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