ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia

Rearrangements of the ALL-1/MLL1 gene underlie the majority of infant acute leukaemias, as well as of therapy-related leukaemias developing in cancer patients treated with inhibitors of topoisomerase II, such as VP16 and doxorubicin. The rearrangements fuse ALL-1 to any of >50 partner genes or to...

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Autores principales: Canaani, E, Nakamura, T, Rozovskaia, T, Smith, S T, Mori, T, Croce, C M, Mazo, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410188/
https://www.ncbi.nlm.nih.gov/pubmed/14970849
http://dx.doi.org/10.1038/sj.bjc.6601639
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author Canaani, E
Nakamura, T
Rozovskaia, T
Smith, S T
Mori, T
Croce, C M
Mazo, A
author_facet Canaani, E
Nakamura, T
Rozovskaia, T
Smith, S T
Mori, T
Croce, C M
Mazo, A
author_sort Canaani, E
collection PubMed
description Rearrangements of the ALL-1/MLL1 gene underlie the majority of infant acute leukaemias, as well as of therapy-related leukaemias developing in cancer patients treated with inhibitors of topoisomerase II, such as VP16 and doxorubicin. The rearrangements fuse ALL-1 to any of >50 partner genes or to itself. Here, we describe the unique features of ALL-1-associated leukaemias, and recent progress in understanding molecular mechanisms involved in the activity of the ALL-1 protein and of its Drosophila homologue TRITHORAX.
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spelling pubmed-24101882009-09-10 ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia Canaani, E Nakamura, T Rozovskaia, T Smith, S T Mori, T Croce, C M Mazo, A Br J Cancer Minireview Rearrangements of the ALL-1/MLL1 gene underlie the majority of infant acute leukaemias, as well as of therapy-related leukaemias developing in cancer patients treated with inhibitors of topoisomerase II, such as VP16 and doxorubicin. The rearrangements fuse ALL-1 to any of >50 partner genes or to itself. Here, we describe the unique features of ALL-1-associated leukaemias, and recent progress in understanding molecular mechanisms involved in the activity of the ALL-1 protein and of its Drosophila homologue TRITHORAX. Nature Publishing Group 2004-02-23 2004-02-17 /pmc/articles/PMC2410188/ /pubmed/14970849 http://dx.doi.org/10.1038/sj.bjc.6601639 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Canaani, E
Nakamura, T
Rozovskaia, T
Smith, S T
Mori, T
Croce, C M
Mazo, A
ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
title ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
title_full ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
title_fullStr ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
title_full_unstemmed ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
title_short ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
title_sort all-1/mll1, a homologue of drosophila trithorax, modifies chromatin and is directly involved in infant acute leukaemia
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410188/
https://www.ncbi.nlm.nih.gov/pubmed/14970849
http://dx.doi.org/10.1038/sj.bjc.6601639
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