ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia

Rearrangements of the ALL-1/MLL1 gene underlie the majority of infant acute leukaemias, as well as of therapy-related leukaemias developing in cancer patients treated with inhibitors of topoisomerase II, such as VP16 and doxorubicin. The rearrangements fuse ALL-1 to any of >50 partner genes or to...

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Detalles Bibliográficos
Autores principales: Canaani, E, Nakamura, T, Rozovskaia, T, Smith, S T, Mori, T, Croce, C M, Mazo, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410188/
https://www.ncbi.nlm.nih.gov/pubmed/14970849
http://dx.doi.org/10.1038/sj.bjc.6601639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410188/
https://www.ncbi.nlm.nih.gov/pubmed/14970849
http://dx.doi.org/10.1038/sj.bjc.6601639

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