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PPAR Gamma and Hepatic Stellate Cells
Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose ac...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410230/ https://www.ncbi.nlm.nih.gov/pubmed/14960159 http://dx.doi.org/10.1186/1476-5926-2-S1-S7 |
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author | Hazra, Saswati Miyahara, Takeo Rippe, Richard A Tsukamoto, Hidekazu |
author_facet | Hazra, Saswati Miyahara, Takeo Rippe, Richard A Tsukamoto, Hidekazu |
author_sort | Hazra, Saswati |
collection | PubMed |
description | Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC. PPAR gamma ligands suppress several markers of HSC activation such as expression of collagen and alpha smooth muscle actin (alpha-SMA), cell proliferation and migration. Expression of PPAR gamma, per se, also inhibits HSC activation. These findings support the role of PPAR gamma in reversion of activated HSC toward their quiescent state. |
format | Text |
id | pubmed-2410230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24102302008-06-05 PPAR Gamma and Hepatic Stellate Cells Hazra, Saswati Miyahara, Takeo Rippe, Richard A Tsukamoto, Hidekazu Comp Hepatol Proceedings Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC. PPAR gamma ligands suppress several markers of HSC activation such as expression of collagen and alpha smooth muscle actin (alpha-SMA), cell proliferation and migration. Expression of PPAR gamma, per se, also inhibits HSC activation. These findings support the role of PPAR gamma in reversion of activated HSC toward their quiescent state. BioMed Central 2004-01-14 /pmc/articles/PMC2410230/ /pubmed/14960159 http://dx.doi.org/10.1186/1476-5926-2-S1-S7 Text en Copyright © 2004 Hazra et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Proceedings Hazra, Saswati Miyahara, Takeo Rippe, Richard A Tsukamoto, Hidekazu PPAR Gamma and Hepatic Stellate Cells |
title | PPAR Gamma and Hepatic Stellate Cells |
title_full | PPAR Gamma and Hepatic Stellate Cells |
title_fullStr | PPAR Gamma and Hepatic Stellate Cells |
title_full_unstemmed | PPAR Gamma and Hepatic Stellate Cells |
title_short | PPAR Gamma and Hepatic Stellate Cells |
title_sort | ppar gamma and hepatic stellate cells |
topic | Proceedings |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410230/ https://www.ncbi.nlm.nih.gov/pubmed/14960159 http://dx.doi.org/10.1186/1476-5926-2-S1-S7 |
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