PPAR Gamma and Hepatic Stellate Cells

Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose ac...

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Detalles Bibliográficos
Autores principales: Hazra, Saswati, Miyahara, Takeo, Rippe, Richard A, Tsukamoto, Hidekazu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410230/
https://www.ncbi.nlm.nih.gov/pubmed/14960159
http://dx.doi.org/10.1186/1476-5926-2-S1-S7
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author Hazra, Saswati
Miyahara, Takeo
Rippe, Richard A
Tsukamoto, Hidekazu
author_facet Hazra, Saswati
Miyahara, Takeo
Rippe, Richard A
Tsukamoto, Hidekazu
author_sort Hazra, Saswati
collection PubMed
description Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC. PPAR gamma ligands suppress several markers of HSC activation such as expression of collagen and alpha smooth muscle actin (alpha-SMA), cell proliferation and migration. Expression of PPAR gamma, per se, also inhibits HSC activation. These findings support the role of PPAR gamma in reversion of activated HSC toward their quiescent state.
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spelling pubmed-24102302008-06-05 PPAR Gamma and Hepatic Stellate Cells Hazra, Saswati Miyahara, Takeo Rippe, Richard A Tsukamoto, Hidekazu Comp Hepatol Proceedings Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC. PPAR gamma ligands suppress several markers of HSC activation such as expression of collagen and alpha smooth muscle actin (alpha-SMA), cell proliferation and migration. Expression of PPAR gamma, per se, also inhibits HSC activation. These findings support the role of PPAR gamma in reversion of activated HSC toward their quiescent state. BioMed Central 2004-01-14 /pmc/articles/PMC2410230/ /pubmed/14960159 http://dx.doi.org/10.1186/1476-5926-2-S1-S7 Text en Copyright © 2004 Hazra et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Hazra, Saswati
Miyahara, Takeo
Rippe, Richard A
Tsukamoto, Hidekazu
PPAR Gamma and Hepatic Stellate Cells
title PPAR Gamma and Hepatic Stellate Cells
title_full PPAR Gamma and Hepatic Stellate Cells
title_fullStr PPAR Gamma and Hepatic Stellate Cells
title_full_unstemmed PPAR Gamma and Hepatic Stellate Cells
title_short PPAR Gamma and Hepatic Stellate Cells
title_sort ppar gamma and hepatic stellate cells
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410230/
https://www.ncbi.nlm.nih.gov/pubmed/14960159
http://dx.doi.org/10.1186/1476-5926-2-S1-S7
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