Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas

Colorectal tumours from MYH polyposis patients display an excess of somatic G : C → T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, S, Lambert, S, Williams, G T, Best, J M, Sampson, J R, Cheadle, J P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410274/
https://www.ncbi.nlm.nih.gov/pubmed/15083190
http://dx.doi.org/10.1038/sj.bjc.6601747
_version_ 1782155967499075584
author Jones, S
Lambert, S
Williams, G T
Best, J M
Sampson, J R
Cheadle, J P
author_facet Jones, S
Lambert, S
Williams, G T
Best, J M
Sampson, J R
Cheadle, J P
author_sort Jones, S
collection PubMed
description Colorectal tumours from MYH polyposis patients display an excess of somatic G : C → T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.005). G : C → T : A transversions in k-ras were significantly more frequent in MYH polyposis adenomas than in sporadic or familial adenomatous polyposis-associated tumours (P⩽0.002), and all resulted in a glycine-to-cysteine substitution at codon 12.
format Text
id pubmed-2410274
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-24102742009-09-10 Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas Jones, S Lambert, S Williams, G T Best, J M Sampson, J R Cheadle, J P Br J Cancer Short Communication Colorectal tumours from MYH polyposis patients display an excess of somatic G : C → T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.005). G : C → T : A transversions in k-ras were significantly more frequent in MYH polyposis adenomas than in sporadic or familial adenomatous polyposis-associated tumours (P⩽0.002), and all resulted in a glycine-to-cysteine substitution at codon 12. Nature Publishing Group 2004-04-19 2004-03-30 /pmc/articles/PMC2410274/ /pubmed/15083190 http://dx.doi.org/10.1038/sj.bjc.6601747 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Jones, S
Lambert, S
Williams, G T
Best, J M
Sampson, J R
Cheadle, J P
Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
title Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
title_full Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
title_fullStr Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
title_full_unstemmed Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
title_short Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
title_sort increased frequency of the k-ras g12c mutation in myh polyposis colorectal adenomas
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410274/
https://www.ncbi.nlm.nih.gov/pubmed/15083190
http://dx.doi.org/10.1038/sj.bjc.6601747
work_keys_str_mv AT joness increasedfrequencyofthekrasg12cmutationinmyhpolyposiscolorectaladenomas
AT lamberts increasedfrequencyofthekrasg12cmutationinmyhpolyposiscolorectaladenomas
AT williamsgt increasedfrequencyofthekrasg12cmutationinmyhpolyposiscolorectaladenomas
AT bestjm increasedfrequencyofthekrasg12cmutationinmyhpolyposiscolorectaladenomas
AT sampsonjr increasedfrequencyofthekrasg12cmutationinmyhpolyposiscolorectaladenomas
AT cheadlejp increasedfrequencyofthekrasg12cmutationinmyhpolyposiscolorectaladenomas

Ejemplares similares