Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas

Colorectal tumours from MYH polyposis patients display an excess of somatic G : C → T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous...

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Detalles Bibliográficos
Autores principales: Jones, S, Lambert, S, Williams, G T, Best, J M, Sampson, J R, Cheadle, J P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410274/
https://www.ncbi.nlm.nih.gov/pubmed/15083190
http://dx.doi.org/10.1038/sj.bjc.6601747

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