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Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression

DNA mismatch repair suppresses gastrointestinal tumorgenesis. Four mammalian E. coli MutL homologues heterodimerize to form three distinct complexes: MLH1/PMS2, MLH1/MLH3, and MLH1/PMS1. To understand the mechanistic contributions of MLH3 and PMS2 in gastrointestinal tumor suppression, we generated...

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Detalles Bibliográficos
Autores principales:	Chen, Peng-Chieh, Kuraguchi, Mari, Velasquez, John, Wang, Yuxun, Yang, Kan, Edwards, Robert, Gillen, Dan, Edelmann, Winfried, Kucherlapati, Raju, Lipkin, Steven M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410297/ https://www.ncbi.nlm.nih.gov/pubmed/18551179 http://dx.doi.org/10.1371/journal.pgen.1000092

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