Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line

Gefitinib (Iressa)–a specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase–has been shown to suppress the activation of EGFR signaling required for cell survival and proliferation in non-small cell lung cancer (NSCLC) cell lines. We recently provided novel evidence that gefit...

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Detalles Bibliográficos
Autores principales: Nishimura, Yukio, Yoshioka, Kiyoko, Bereczky, Biborka, Itoh, Kazuyuki
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2412912/
https://www.ncbi.nlm.nih.gov/pubmed/18492291
http://dx.doi.org/10.1186/1476-4598-7-42

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