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IKKβ/NF-κB and the miscreant macrophage
Macrophage activation relies on complex intracellular signaling processes that integrate the need for rapid inflammatory responses to pathogens with the need to resolve inflammation without permanent harm to normal tissues. Patterns of aberrant macrophage activation characterize and sustain disorder...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413023/ https://www.ncbi.nlm.nih.gov/pubmed/18519650 http://dx.doi.org/10.1084/jem.20081056 |
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author | Timmer, Anjuli M. Nizet, Victor |
author_facet | Timmer, Anjuli M. Nizet, Victor |
author_sort | Timmer, Anjuli M. |
collection | PubMed |
description | Macrophage activation relies on complex intracellular signaling processes that integrate the need for rapid inflammatory responses to pathogens with the need to resolve inflammation without permanent harm to normal tissues. Patterns of aberrant macrophage activation characterize and sustain disorders of chronic inflammation, infection, and cancer. New studies now show a role for the NF-κB activator IKKβ in promoting an alternative, immunosuppressive pattern of macrophage activation, which limits the cell's tumoricidal and bactericidal capacities. As cancers and pathogens may have evolved multiple mechanisms to manipulate macrophages for their own survival, is there anything we can do about it? |
format | Text |
id | pubmed-2413023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-24130232008-12-09 IKKβ/NF-κB and the miscreant macrophage Timmer, Anjuli M. Nizet, Victor J Exp Med Commentaries Macrophage activation relies on complex intracellular signaling processes that integrate the need for rapid inflammatory responses to pathogens with the need to resolve inflammation without permanent harm to normal tissues. Patterns of aberrant macrophage activation characterize and sustain disorders of chronic inflammation, infection, and cancer. New studies now show a role for the NF-κB activator IKKβ in promoting an alternative, immunosuppressive pattern of macrophage activation, which limits the cell's tumoricidal and bactericidal capacities. As cancers and pathogens may have evolved multiple mechanisms to manipulate macrophages for their own survival, is there anything we can do about it? The Rockefeller University Press 2008-06-09 /pmc/articles/PMC2413023/ /pubmed/18519650 http://dx.doi.org/10.1084/jem.20081056 Text en © 2008 Timmer and Nizet This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Commentaries Timmer, Anjuli M. Nizet, Victor IKKβ/NF-κB and the miscreant macrophage |
title | IKKβ/NF-κB and the miscreant macrophage |
title_full | IKKβ/NF-κB and the miscreant macrophage |
title_fullStr | IKKβ/NF-κB and the miscreant macrophage |
title_full_unstemmed | IKKβ/NF-κB and the miscreant macrophage |
title_short | IKKβ/NF-κB and the miscreant macrophage |
title_sort | ikkβ/nf-κb and the miscreant macrophage |
topic | Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413023/ https://www.ncbi.nlm.nih.gov/pubmed/18519650 http://dx.doi.org/10.1084/jem.20081056 |
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