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IKKβ/NF-κB and the miscreant macrophage

Macrophage activation relies on complex intracellular signaling processes that integrate the need for rapid inflammatory responses to pathogens with the need to resolve inflammation without permanent harm to normal tissues. Patterns of aberrant macrophage activation characterize and sustain disorder...

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Detalles Bibliográficos
Autores principales: Timmer, Anjuli M., Nizet, Victor
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413023/
https://www.ncbi.nlm.nih.gov/pubmed/18519650
http://dx.doi.org/10.1084/jem.20081056
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author Timmer, Anjuli M.
Nizet, Victor
author_facet Timmer, Anjuli M.
Nizet, Victor
author_sort Timmer, Anjuli M.
collection PubMed
description Macrophage activation relies on complex intracellular signaling processes that integrate the need for rapid inflammatory responses to pathogens with the need to resolve inflammation without permanent harm to normal tissues. Patterns of aberrant macrophage activation characterize and sustain disorders of chronic inflammation, infection, and cancer. New studies now show a role for the NF-κB activator IKKβ in promoting an alternative, immunosuppressive pattern of macrophage activation, which limits the cell's tumoricidal and bactericidal capacities. As cancers and pathogens may have evolved multiple mechanisms to manipulate macrophages for their own survival, is there anything we can do about it?
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spelling pubmed-24130232008-12-09 IKKβ/NF-κB and the miscreant macrophage Timmer, Anjuli M. Nizet, Victor J Exp Med Commentaries Macrophage activation relies on complex intracellular signaling processes that integrate the need for rapid inflammatory responses to pathogens with the need to resolve inflammation without permanent harm to normal tissues. Patterns of aberrant macrophage activation characterize and sustain disorders of chronic inflammation, infection, and cancer. New studies now show a role for the NF-κB activator IKKβ in promoting an alternative, immunosuppressive pattern of macrophage activation, which limits the cell's tumoricidal and bactericidal capacities. As cancers and pathogens may have evolved multiple mechanisms to manipulate macrophages for their own survival, is there anything we can do about it? The Rockefeller University Press 2008-06-09 /pmc/articles/PMC2413023/ /pubmed/18519650 http://dx.doi.org/10.1084/jem.20081056 Text en © 2008 Timmer and Nizet This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentaries
Timmer, Anjuli M.
Nizet, Victor
IKKβ/NF-κB and the miscreant macrophage
title IKKβ/NF-κB and the miscreant macrophage
title_full IKKβ/NF-κB and the miscreant macrophage
title_fullStr IKKβ/NF-κB and the miscreant macrophage
title_full_unstemmed IKKβ/NF-κB and the miscreant macrophage
title_short IKKβ/NF-κB and the miscreant macrophage
title_sort ikkβ/nf-κb and the miscreant macrophage
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413023/
https://www.ncbi.nlm.nih.gov/pubmed/18519650
http://dx.doi.org/10.1084/jem.20081056
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