Cargando…

Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis

The high rate of mortality in patients with sepsis results from an inappropriately amplified systemic inflammatory response to infection. Toll-like receptors (TLRs) are important for the activation of innate immunity against microbial pathogens. We demonstrate a critical role of TLR9 in the dysregul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Plitas, George, Burt, Bryan M., Nguyen, Hoang M., Bamboat, Zubin M., DeMatteo, Ronald P.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413026/ https://www.ncbi.nlm.nih.gov/pubmed/18474631 http://dx.doi.org/10.1084/jem.20080162

Ejemplares similares

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
por: Huston, Jared M., et al.
Publicado: (2006)

Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10
por: Kelly-Scumpia, Kindra M., et al.
Publicado: (2010)

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9–driven antiinflammatory cytokine production
por: González-Navajas, Jose M., et al.
Publicado: (2010)

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
por: Coban, Cevayir, et al.
Publicado: (2005)

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
por: Lund, Jennifer, et al.
Publicado: (2003)

Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis
por: Lohner, Ralph, et al.
Publicado: (2013)

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
por: Ewald, Sarah E., et al.
Publicado: (2011)

Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection
por: Didierlaurent, Arnaud, et al.
Publicado: (2008)

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8
por: Maelfait, Jonathan, et al.
Publicado: (2008)

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
por: Lau, Christina M., et al.
Publicado: (2005)

Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-κB
por: Gourzi, Polyxeni, et al.
Publicado: (2007)

Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling
por: Choe, Jung-Yoon, et al.
Publicado: (2003)

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
por: Kadowaki, Norimitsu, et al.
Publicado: (2001)

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen
por: Eisenbarth, Stephanie C., et al.
Publicado: (2002)

Interferon-α and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets
por: Ito, Tomoki, et al.
Publicado: (2002)

Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production
por: Cao, Wei, et al.
Publicado: (2006)

The 2′-O-methylation status of a single guanosine controls transfer RNA–mediated Toll-like receptor 7 activation or inhibition
por: Jöckel, Stefanie, et al.
Publicado: (2012)

Monocytes Heterozygous for the Asp299Gly and Thr399Ile Mutations in the Toll-like Receptor 4 Gene Show No Deficit in Lipopolysaccharide Signalling
por: Erridge, Clett, et al.
Publicado: (2003)

Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1
por: Conner, James R., et al.
Publicado: (2008)

Epstein-Barr virus (EBV)–encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3
por: Iwakiri, Dai, et al.
Publicado: (2009)

Time-serial expression of toll-like receptor 4 signaling during polymicrobial sepsis in rats
por: Lee, En-Pei, et al.
Publicado: (2022)

Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2
por: Lee, Sung Kyun, et al.
Publicado: (2015)

Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4
por: Burns, Kimberly, et al.
Publicado: (2003)

Role of HMGB1 in apoptosis-mediated sepsis lethality
por: Qin, Shixin, et al.
Publicado: (2006)

RAGE: Exacting a toll on the host in response to polymicrobial sepsis and Listeria monocytogenes
por: Clynes, Raphael, et al.
Publicado: (2007)

Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
por: Marki, Alex, et al.
Publicado: (2020)

FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis
por: Clatworthy, Menna R., et al.
Publicado: (2004)

Resistance to Leishmania major is Linked to the H2 Region on Chromosome 17 and to Chromosome 9
por: Roberts, Lynden J., et al.
Publicado: (1997)

The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)
por: Muzio, Marta, et al.
Publicado: (1998)

Germline SAMD9L truncation variants trigger global translational repression
por: Allenspach, Eric J., et al.
Publicado: (2021)

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X
por: Naik, Edwina, et al.
Publicado: (2014)

Cadherin-11 Provides Specific Cellular Adhesion between Fibroblast-like Synoviocytes
por: Valencia, Xavier, et al.
Publicado: (2004)

LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor
por: Lu, Xin-Jiang, et al.
Publicado: (2013)

TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
por: Spiller, Stephan, et al.
Publicado: (2008)

Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response
por: Fang, Terry C., et al.
Publicado: (2012)

Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis
por: da Costa, Cristiana E.T., et al.
Publicado: (2005)

Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function
por: Lehnertz, Bernhard, et al.
Publicado: (2010)

MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection
por: Brandl, Katharina, et al.
Publicado: (2007)

Murine CD9 Is the Receptor for Pregnancy-specific Glycoprotein 17
por: Waterhouse, Roseann, et al.
Publicado: (2002)

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase
por: Nathan, Carl, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_o6sf60kr4rqjkfjd2ve0lfb8e7