Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis

CD40, a member of the tumor necrosis factor (TNF) receptor family, plays an essential role in T cell–dependent immune responses. Because CD40 is widely expressed on the surface of tumor cells in various B cell malignancies, deregulated CD40 signaling has been suggested to contribute to lymphomagenes...

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Detalles Bibliográficos
Autores principales: Hömig-Hölzel, Cornelia, Hojer, Caroline, Rastelli, Julia, Casola, Stefano, Strobl, Lothar J., Müller, Werner, Quintanilla-Martinez, Leticia, Gewies, Andreas, Ruland, Jürgen, Rajewsky, Klaus, Zimber-Strobl, Ursula
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413030/
https://www.ncbi.nlm.nih.gov/pubmed/18490492
http://dx.doi.org/10.1084/jem.20080238

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