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Organization of multiprotein complexes at cell–cell junctions

The formation of stable cell–cell contacts is required for the generation of barrier-forming sheets of epithelial and endothelial cells. During various physiological processes like tissue development, wound healing or tumorigenesis, cellular junctions are reorganized to allow the release or the inco...

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Detalles Bibliográficos
Autor principal: Ebnet, Klaus
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413109/
https://www.ncbi.nlm.nih.gov/pubmed/18365233
http://dx.doi.org/10.1007/s00418-008-0418-7
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author Ebnet, Klaus
author_facet Ebnet, Klaus
author_sort Ebnet, Klaus
collection PubMed
description The formation of stable cell–cell contacts is required for the generation of barrier-forming sheets of epithelial and endothelial cells. During various physiological processes like tissue development, wound healing or tumorigenesis, cellular junctions are reorganized to allow the release or the incorporation of individual cells. Cell–cell contact formation is regulated by multiprotein complexes which are localized at specific structures along the lateral cell junctions like the tight junctions and adherens junctions and which are targeted to these site through their association with cell adhesion molecules. Recent evidence indicates that several major protein complexes exist which have distinct functions during junction formation. However, this evidence also indicates that their composition is dynamic and subject to changes depending on the state of junction maturation. Thus, cell–cell contact formation and integrity is regulated by a complex network of protein complexes. Imbalancing this network by oncogenic proteins or pathogens results in barrier breakdown and eventually in cancer. Here, I will review the molecular organization of the major multiprotein complexes at junctions of epithelial cells and discuss their function in cell–cell contact formation and maintenance.
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spelling pubmed-24131092008-06-05 Organization of multiprotein complexes at cell–cell junctions Ebnet, Klaus Histochem Cell Biol Review The formation of stable cell–cell contacts is required for the generation of barrier-forming sheets of epithelial and endothelial cells. During various physiological processes like tissue development, wound healing or tumorigenesis, cellular junctions are reorganized to allow the release or the incorporation of individual cells. Cell–cell contact formation is regulated by multiprotein complexes which are localized at specific structures along the lateral cell junctions like the tight junctions and adherens junctions and which are targeted to these site through their association with cell adhesion molecules. Recent evidence indicates that several major protein complexes exist which have distinct functions during junction formation. However, this evidence also indicates that their composition is dynamic and subject to changes depending on the state of junction maturation. Thus, cell–cell contact formation and integrity is regulated by a complex network of protein complexes. Imbalancing this network by oncogenic proteins or pathogens results in barrier breakdown and eventually in cancer. Here, I will review the molecular organization of the major multiprotein complexes at junctions of epithelial cells and discuss their function in cell–cell contact formation and maintenance. Springer-Verlag 2008-03-26 2008-07 /pmc/articles/PMC2413109/ /pubmed/18365233 http://dx.doi.org/10.1007/s00418-008-0418-7 Text en © Springer-Verlag 2008
spellingShingle Review
Ebnet, Klaus
Organization of multiprotein complexes at cell–cell junctions
title Organization of multiprotein complexes at cell–cell junctions
title_full Organization of multiprotein complexes at cell–cell junctions
title_fullStr Organization of multiprotein complexes at cell–cell junctions
title_full_unstemmed Organization of multiprotein complexes at cell–cell junctions
title_short Organization of multiprotein complexes at cell–cell junctions
title_sort organization of multiprotein complexes at cell–cell junctions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413109/
https://www.ncbi.nlm.nih.gov/pubmed/18365233
http://dx.doi.org/10.1007/s00418-008-0418-7
work_keys_str_mv AT ebnetklaus organizationofmultiproteincomplexesatcellcelljunctions