Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation

OBJECTIVE: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy. MATERIALS AND METHODS: We present genetic evidence that the meningi...

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Autores principales: Ammerlaan, A. C. J., Houben, M. P. W. A., Tijssen, C. C., Wesseling, P., Hulsebos, T. J. M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413122/
https://www.ncbi.nlm.nih.gov/pubmed/18236049
http://dx.doi.org/10.1007/s00381-007-0578-0
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author Ammerlaan, A. C. J.
Houben, M. P. W. A.
Tijssen, C. C.
Wesseling, P.
Hulsebos, T. J. M.
author_facet Ammerlaan, A. C. J.
Houben, M. P. W. A.
Tijssen, C. C.
Wesseling, P.
Hulsebos, T. J. M.
author_sort Ammerlaan, A. C. J.
collection PubMed
description OBJECTIVE: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy. MATERIALS AND METHODS: We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour. CONCLUSION: This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.
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spelling pubmed-24131222008-06-05 Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation Ammerlaan, A. C. J. Houben, M. P. W. A. Tijssen, C. C. Wesseling, P. Hulsebos, T. J. M. Childs Nerv Syst Case Report OBJECTIVE: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy. MATERIALS AND METHODS: We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour. CONCLUSION: This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours. Springer-Verlag 2008-01-31 2008-07 /pmc/articles/PMC2413122/ /pubmed/18236049 http://dx.doi.org/10.1007/s00381-007-0578-0 Text en © The Author(s) 2008
spellingShingle Case Report
Ammerlaan, A. C. J.
Houben, M. P. W. A.
Tijssen, C. C.
Wesseling, P.
Hulsebos, T. J. M.
Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
title Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
title_full Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
title_fullStr Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
title_full_unstemmed Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
title_short Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation
title_sort secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline ini1 mutation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413122/
https://www.ncbi.nlm.nih.gov/pubmed/18236049
http://dx.doi.org/10.1007/s00381-007-0578-0
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