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Erwin Schroedinger, Francis Crick and epigenetic stability

Schroedinger's book 'What is Life?' is widely credited for having played a crucial role in development of molecular and cellular biology. My essay revisits the issues raised by this book from the modern perspective of epigenetics and systems biology. I contrast two classes of potentia...

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Detalles Bibliográficos
Autor principal: Ogryzko, Vasily V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413215/
https://www.ncbi.nlm.nih.gov/pubmed/18419815
http://dx.doi.org/10.1186/1745-6150-3-15
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author Ogryzko, Vasily V
author_facet Ogryzko, Vasily V
author_sort Ogryzko, Vasily V
collection PubMed
description Schroedinger's book 'What is Life?' is widely credited for having played a crucial role in development of molecular and cellular biology. My essay revisits the issues raised by this book from the modern perspective of epigenetics and systems biology. I contrast two classes of potential mechanisms of epigenetic stability: 'epigenetic templating' and 'systems biology' approaches, and consider them from the point of view expressed by Schroedinger. I also discuss how quantum entanglement, a nonclassical feature of quantum mechanics, can help to address the 'problem of small numbers' that led Schroedinger to promote the idea of a molecular code-script for explaining the stability of biological order.
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spelling pubmed-24132152008-06-06 Erwin Schroedinger, Francis Crick and epigenetic stability Ogryzko, Vasily V Biol Direct Hypothesis Schroedinger's book 'What is Life?' is widely credited for having played a crucial role in development of molecular and cellular biology. My essay revisits the issues raised by this book from the modern perspective of epigenetics and systems biology. I contrast two classes of potential mechanisms of epigenetic stability: 'epigenetic templating' and 'systems biology' approaches, and consider them from the point of view expressed by Schroedinger. I also discuss how quantum entanglement, a nonclassical feature of quantum mechanics, can help to address the 'problem of small numbers' that led Schroedinger to promote the idea of a molecular code-script for explaining the stability of biological order. BioMed Central 2008-04-17 /pmc/articles/PMC2413215/ /pubmed/18419815 http://dx.doi.org/10.1186/1745-6150-3-15 Text en Copyright © 2008 Ogryzko; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis
Ogryzko, Vasily V
Erwin Schroedinger, Francis Crick and epigenetic stability
title Erwin Schroedinger, Francis Crick and epigenetic stability
title_full Erwin Schroedinger, Francis Crick and epigenetic stability
title_fullStr Erwin Schroedinger, Francis Crick and epigenetic stability
title_full_unstemmed Erwin Schroedinger, Francis Crick and epigenetic stability
title_short Erwin Schroedinger, Francis Crick and epigenetic stability
title_sort erwin schroedinger, francis crick and epigenetic stability
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413215/
https://www.ncbi.nlm.nih.gov/pubmed/18419815
http://dx.doi.org/10.1186/1745-6150-3-15
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