Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

BACKGROUND: Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD(50 )of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. This study was undertaken to produce recombinant huBChE fused to human serum...

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Detalles Bibliográficos
Autores principales: Huang, Yue-Jin, Lundy, Paul M, Lazaris, Anthoula, Huang, Yue, Baldassarre, Hernan, Wang, Bin, Turcotte, Carl, Côté, Mélanie, Bellemare, Annie, Bilodeau, Annie S, Brouillard, Sandra, Touati, Madjid, Herskovits, Peter, Bégin, Isabelle, Neveu, Nathalie, Brochu, Eric, Pierson, Janice, Hockley, Duncan K, Cerasoli, Douglas M, Lenz, David E, Wilgus, Harvey, Karatzas, Costas N, Langermann, Solomon
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2415180/
https://www.ncbi.nlm.nih.gov/pubmed/18485214
http://dx.doi.org/10.1186/1472-6750-8-50

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