Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance

BACKGROUND: The transcription factor Pax6 is expressed by many cell types in the developing eye. Eyes do not form in homozygous loss-of-function mouse mutants (Pax6(Sey/Sey)) and are abnormally small in Pax6(Sey/+ )mutants. Eyes are also abnormally small in PAX77 mice expressing multiple copies of h...

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Detalles Bibliográficos
Autores principales: Manuel, Martine, Pratt, Thomas, Liu, Min, Jeffery, Glen, Price, David J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2422841/
https://www.ncbi.nlm.nih.gov/pubmed/18507827
http://dx.doi.org/10.1186/1471-213X-8-59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2422841/
https://www.ncbi.nlm.nih.gov/pubmed/18507827
http://dx.doi.org/10.1186/1471-213X-8-59

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