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Exploring allosteric coupling in the α-subunit of Heterotrimeric G proteins using evolutionary and ensemble-based approaches

BACKGROUND: Allosteric coupling, which can be defined as propagation of a perturbation at one region of the protein molecule (such as ligand binding) to distant sites in the same molecule, constitutes the most general mechanism of regulation of protein function. However, unlike molecular details of...

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Detalles Bibliográficos
Autores principales:	Sayar, Kemal, Uğur, Özlem, Liu, Tong, Hilser, Vincent J, Onaran, Ongun
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2422842/ https://www.ncbi.nlm.nih.gov/pubmed/18454845 http://dx.doi.org/10.1186/1472-6807-8-23

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