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Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabilize the outer mitochondrial membrane, thereby committing cells to apoptosis, whereas Bcl-XL inhibits this process. Two different models of Bcl-XL function have been proposed. In one, Bcl-XL binds to a...

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Detalles Bibliográficos
Autores principales:	Billen, Lieven P, Kokoski, Candis L, Lovell, Jonathan F, Leber, Brian, Andrews, David W
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2422857/ https://www.ncbi.nlm.nih.gov/pubmed/18547146 http://dx.doi.org/10.1371/journal.pbio.0060147

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