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The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer

Dietary peroxisome proliferator-activated receptor (PPAR)γ ligands, linoleic acid (LA) and conjugated linoleic acid (CLA), showed anticancer effects in colorectal carcinoma cells. LA is metabolized by two pathways. Cyclooxygenase (COX)-2 produces procarcinogenic prostaglandin E2, whereas 15-lipoxyge...

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Autor principal: Kuniyasu, Hiroki
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2422868/
https://www.ncbi.nlm.nih.gov/pubmed/18551182
http://dx.doi.org/10.1155/2008/529720
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author Kuniyasu, Hiroki
author_facet Kuniyasu, Hiroki
author_sort Kuniyasu, Hiroki
collection PubMed
description Dietary peroxisome proliferator-activated receptor (PPAR)γ ligands, linoleic acid (LA) and conjugated linoleic acid (CLA), showed anticancer effects in colorectal carcinoma cells. LA is metabolized by two pathways. Cyclooxygenase (COX)-2 produces procarcinogenic prostaglandin E2, whereas 15-lipoxygenase (LOX)-1 produces PPARγ ligands. The 15LOX-1 pathway, which is dominant in colorectal adenomas, was downregulated and inversely COX-2 was upregulated in colorectal cancer. LA and CLA inhibited peritoneal metastasis of colorectal cancer cells in nude mice. The inhibitory effect was abrogated by PPARγ antisense treatment. A continuous LA treatment provided cancer cells quiescence. These quiescent cells formed dormant nests in nude mice administrated LA. The quiescent and dormant cells showed downregulated PPARγ and upregulated nucleostemin. Thus, short-term exposure to dietary PPARγ ligands inhibits cancer metastasis, whereas consistent exposure to LA provides quiescent/dormant status with possible induction of cancer stem and/or progenitor phenotype. The complicated roles of dietary PPARγ ligands are needed to examine further.
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spelling pubmed-24228682008-06-12 The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer Kuniyasu, Hiroki PPAR Res Review Article Dietary peroxisome proliferator-activated receptor (PPAR)γ ligands, linoleic acid (LA) and conjugated linoleic acid (CLA), showed anticancer effects in colorectal carcinoma cells. LA is metabolized by two pathways. Cyclooxygenase (COX)-2 produces procarcinogenic prostaglandin E2, whereas 15-lipoxygenase (LOX)-1 produces PPARγ ligands. The 15LOX-1 pathway, which is dominant in colorectal adenomas, was downregulated and inversely COX-2 was upregulated in colorectal cancer. LA and CLA inhibited peritoneal metastasis of colorectal cancer cells in nude mice. The inhibitory effect was abrogated by PPARγ antisense treatment. A continuous LA treatment provided cancer cells quiescence. These quiescent cells formed dormant nests in nude mice administrated LA. The quiescent and dormant cells showed downregulated PPARγ and upregulated nucleostemin. Thus, short-term exposure to dietary PPARγ ligands inhibits cancer metastasis, whereas consistent exposure to LA provides quiescent/dormant status with possible induction of cancer stem and/or progenitor phenotype. The complicated roles of dietary PPARγ ligands are needed to examine further. Hindawi Publishing Corporation 2008 2008-06-05 /pmc/articles/PMC2422868/ /pubmed/18551182 http://dx.doi.org/10.1155/2008/529720 Text en Copyright © 2008 Hiroki Kuniyasu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kuniyasu, Hiroki
The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer
title The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer
title_full The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer
title_fullStr The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer
title_full_unstemmed The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer
title_short The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer
title_sort roles of dietary pparγ ligands for metastasis in colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2422868/
https://www.ncbi.nlm.nih.gov/pubmed/18551182
http://dx.doi.org/10.1155/2008/529720
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