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Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin

Cohesin is a protein complex that regulates sister chromatid cohesin during cell division. Malfunction in chromatid cohesin results in chromosome missegregation and aneuploidy. Here, we report that mutations of MCD1 and PDS5, two major components of cohesin in budding yeast, cause apoptotic cell dea...

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Detalles Bibliográficos
Autores principales: Ren, Qun, Yang, Hui, Gao, Bifeng, Zhang, Zhaojie
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423420/
https://www.ncbi.nlm.nih.gov/pubmed/18551189
http://dx.doi.org/10.1155/2008/634283
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author Ren, Qun
Yang, Hui
Gao, Bifeng
Zhang, Zhaojie
author_facet Ren, Qun
Yang, Hui
Gao, Bifeng
Zhang, Zhaojie
author_sort Ren, Qun
collection PubMed
description Cohesin is a protein complex that regulates sister chromatid cohesin during cell division. Malfunction in chromatid cohesin results in chromosome missegregation and aneuploidy. Here, we report that mutations of MCD1 and PDS5, two major components of cohesin in budding yeast, cause apoptotic cell death, which is characterized by externalization of phosphatidylserine at cytoplasmic membrane, chromatin condensation and fragmentation, and ROS production. Microarray analysis suggests that the cell death caused by mutation of MCD1 or PDS5 is due to the internal stress response, contrasting to the environmental or external stress response induced by external stimuli, such as hydrogen peroxide. A common feature shared by the internal stress response and external stress response is the response to stimulus, including response to DNA damage, mitochondria functions, and oxidative stress, which play an important role in yeast apoptotic cell death.
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spelling pubmed-24234202008-06-12 Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin Ren, Qun Yang, Hui Gao, Bifeng Zhang, Zhaojie Comp Funct Genomics Research Article Cohesin is a protein complex that regulates sister chromatid cohesin during cell division. Malfunction in chromatid cohesin results in chromosome missegregation and aneuploidy. Here, we report that mutations of MCD1 and PDS5, two major components of cohesin in budding yeast, cause apoptotic cell death, which is characterized by externalization of phosphatidylserine at cytoplasmic membrane, chromatin condensation and fragmentation, and ROS production. Microarray analysis suggests that the cell death caused by mutation of MCD1 or PDS5 is due to the internal stress response, contrasting to the environmental or external stress response induced by external stimuli, such as hydrogen peroxide. A common feature shared by the internal stress response and external stress response is the response to stimulus, including response to DNA damage, mitochondria functions, and oxidative stress, which play an important role in yeast apoptotic cell death. Hindawi Publishing Corporation 2008 2008-06-09 /pmc/articles/PMC2423420/ /pubmed/18551189 http://dx.doi.org/10.1155/2008/634283 Text en Copyright © 2008 Qun Ren et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ren, Qun
Yang, Hui
Gao, Bifeng
Zhang, Zhaojie
Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin
title Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin
title_full Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin
title_fullStr Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin
title_full_unstemmed Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin
title_short Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin
title_sort global transcriptional analysis of yeast cell death induced by mutation of sister chromatid cohesin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423420/
https://www.ncbi.nlm.nih.gov/pubmed/18551189
http://dx.doi.org/10.1155/2008/634283
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