Pathogenesis of Cholesterol Gallstones

Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation, namely bile that becomes supersaturated with cholesterol, cholesterol nucleation leading to crystal formation and finally retention of the crystals in the gallbladder resulting in stone formatio...

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Detalles Bibliográficos
Autores principales: Strasberg, Steven M., Clavien, Pierre-Alain, Harvey, P. Robert C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423600/
https://www.ncbi.nlm.nih.gov/pubmed/2043512
http://dx.doi.org/10.1155/1991/61741
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author Strasberg, Steven M.
Clavien, Pierre-Alain
Harvey, P. Robert C.
author_facet Strasberg, Steven M.
Clavien, Pierre-Alain
Harvey, P. Robert C.
author_sort Strasberg, Steven M.
collection PubMed
description Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation, namely bile that becomes supersaturated with cholesterol, cholesterol nucleation leading to crystal formation and finally retention of the crystals in the gallbladder resulting in stone formation. Supersaturation is common but nucleation into crystals probably requires protein nucleating factors. Impaired motility of the gallbladder causes crystal retention and is probably very important in stone formation.
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spelling pubmed-24236002008-07-08 Pathogenesis of Cholesterol Gallstones Strasberg, Steven M. Clavien, Pierre-Alain Harvey, P. Robert C. HPB Surg Research Article Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation, namely bile that becomes supersaturated with cholesterol, cholesterol nucleation leading to crystal formation and finally retention of the crystals in the gallbladder resulting in stone formation. Supersaturation is common but nucleation into crystals probably requires protein nucleating factors. Impaired motility of the gallbladder causes crystal retention and is probably very important in stone formation. Hindawi Publishing Corporation 1991 /pmc/articles/PMC2423600/ /pubmed/2043512 http://dx.doi.org/10.1155/1991/61741 Text en Copyright © 1991 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Strasberg, Steven M.
Clavien, Pierre-Alain
Harvey, P. Robert C.
Pathogenesis of Cholesterol Gallstones
title Pathogenesis of Cholesterol Gallstones
title_full Pathogenesis of Cholesterol Gallstones
title_fullStr Pathogenesis of Cholesterol Gallstones
title_full_unstemmed Pathogenesis of Cholesterol Gallstones
title_short Pathogenesis of Cholesterol Gallstones
title_sort pathogenesis of cholesterol gallstones
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423600/
https://www.ncbi.nlm.nih.gov/pubmed/2043512
http://dx.doi.org/10.1155/1991/61741
work_keys_str_mv AT strasbergstevenm pathogenesisofcholesterolgallstones
AT clavienpierrealain pathogenesisofcholesterolgallstones
AT harveyprobertc pathogenesisofcholesterolgallstones

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