A Regulatory Role for NBS1 in Strand-Specific Mutagenesis during Somatic Hypermutation

Activation-induced cytidine deaminase (AID) is believed to initiate somatic hypermutation (SHM) by deamination of deoxycytidines to deoxyuridines within the immunoglobulin variable regions genes. The deaminated bases can subsequently be replicated over, processed by base excision repair or mismatch...

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Detalles Bibliográficos
Autores principales: Du, Likun, Dunn-Walters, Deborah K., Chrzanowska, Krystyna H., Stankovic, Tanja, Kotnis, Ashwin, Li, Xin, Lu, Jiayi, Eggertsen, Gösta, Brittain, Claire, Popov, Sergey W., Gennery, Andrew R., Taylor, A. Malcolm R., Pan-Hammarström, Qiang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423615/
https://www.ncbi.nlm.nih.gov/pubmed/18575580
http://dx.doi.org/10.1371/journal.pone.0002482

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