Cargando…
Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice
Increased amounts of intestinal endotoxin are absorbed in obstructive jaundice. The precise mechanism is not known but the increased absorption may arise from alterations in the luminal contents, in the intestinal flora, in the gut wall or in interactions between all three. To examine the effects of...
Autores principales: | , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
1996
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423832/ https://www.ncbi.nlm.nih.gov/pubmed/9187547 http://dx.doi.org/10.1155/1996/43159 |
_version_ | 1782156191117344768 |
---|---|
author | Quraishy, M. Saeed Chescoe, Dawn Mullervy, Jenny Coates, Marie Hinton, Richard H. Bailey, Michael E. |
author_facet | Quraishy, M. Saeed Chescoe, Dawn Mullervy, Jenny Coates, Marie Hinton, Richard H. Bailey, Michael E. |
author_sort | Quraishy, M. Saeed |
collection | PubMed |
description | Increased amounts of intestinal endotoxin are absorbed in obstructive jaundice. The precise mechanism is not known but the increased absorption may arise from alterations in the luminal contents, in the intestinal flora, in the gut wall or in interactions between all three. To examine the effects of the intestinal flora we have compared the morphological changes in the small intestine in obstructive jaundice in germ free and conventional rats while the effects of bile constituents have been examined by addition of bile constituents to the diet of bile duct ligated rats. Changes in the intestine were examined, histologically, by enzyme histochemistry, and by transmission and scanning electron microscopy. The results showed no differences in response between germ free and conventional rats. Feeding of diets containing bile salts exacerbated the lesion. Feeding of diets containing cholesterol, however, reduced the degree of intestinal changes produced by cholestasis and completely antagonised the increase in damage caused by feeding of bile salts. |
format | Text |
id | pubmed-2423832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-24238322008-07-08 Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice Quraishy, M. Saeed Chescoe, Dawn Mullervy, Jenny Coates, Marie Hinton, Richard H. Bailey, Michael E. HPB Surg Research Article Increased amounts of intestinal endotoxin are absorbed in obstructive jaundice. The precise mechanism is not known but the increased absorption may arise from alterations in the luminal contents, in the intestinal flora, in the gut wall or in interactions between all three. To examine the effects of the intestinal flora we have compared the morphological changes in the small intestine in obstructive jaundice in germ free and conventional rats while the effects of bile constituents have been examined by addition of bile constituents to the diet of bile duct ligated rats. Changes in the intestine were examined, histologically, by enzyme histochemistry, and by transmission and scanning electron microscopy. The results showed no differences in response between germ free and conventional rats. Feeding of diets containing bile salts exacerbated the lesion. Feeding of diets containing cholesterol, however, reduced the degree of intestinal changes produced by cholestasis and completely antagonised the increase in damage caused by feeding of bile salts. Hindawi Publishing Corporation 1996 /pmc/articles/PMC2423832/ /pubmed/9187547 http://dx.doi.org/10.1155/1996/43159 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Quraishy, M. Saeed Chescoe, Dawn Mullervy, Jenny Coates, Marie Hinton, Richard H. Bailey, Michael E. Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice |
title | Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice |
title_full | Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice |
title_fullStr | Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice |
title_full_unstemmed | Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice |
title_short | Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice |
title_sort | influence of the gut microflora and of biliary constituents on morphological changes in the small intestine in obstructive jaundice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423832/ https://www.ncbi.nlm.nih.gov/pubmed/9187547 http://dx.doi.org/10.1155/1996/43159 |
work_keys_str_mv | AT quraishymsaeed influenceofthegutmicrofloraandofbiliaryconstituentsonmorphologicalchangesinthesmallintestineinobstructivejaundice AT chescoedawn influenceofthegutmicrofloraandofbiliaryconstituentsonmorphologicalchangesinthesmallintestineinobstructivejaundice AT mullervyjenny influenceofthegutmicrofloraandofbiliaryconstituentsonmorphologicalchangesinthesmallintestineinobstructivejaundice AT coatesmarie influenceofthegutmicrofloraandofbiliaryconstituentsonmorphologicalchangesinthesmallintestineinobstructivejaundice AT hintonrichardh influenceofthegutmicrofloraandofbiliaryconstituentsonmorphologicalchangesinthesmallintestineinobstructivejaundice AT baileymichaele influenceofthegutmicrofloraandofbiliaryconstituentsonmorphologicalchangesinthesmallintestineinobstructivejaundice |