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Recognition of Intrabiliary Hepatic Metastases From Colorectal Adenocarcinoma

Intrinsic involvement of bile ducts, by metastatic colorectal adenocarcinoma growing from within or invading the lumen of bile ducts, is not a well recognized pattern of tumor growth. Clinical, radiographic, operative, and histopathologic aspects of 15 patients with intrabiliary colorectal metastase...

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Autores principales: Povoski, Stephen P., Klimstra, David S., Brown, Karen T., Schwartz, Lawrence H., Kurtz, Robert C., Jarnagin, William R., Fong, Yuman, Blumgart, Leslie H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424001/
https://www.ncbi.nlm.nih.gov/pubmed/10977117
http://dx.doi.org/10.1155/2000/17619
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author Povoski, Stephen P.
Klimstra, David S.
Brown, Karen T.
Schwartz, Lawrence H.
Kurtz, Robert C.
Jarnagin, William R.
Fong, Yuman
Blumgart, Leslie H.
author_facet Povoski, Stephen P.
Klimstra, David S.
Brown, Karen T.
Schwartz, Lawrence H.
Kurtz, Robert C.
Jarnagin, William R.
Fong, Yuman
Blumgart, Leslie H.
author_sort Povoski, Stephen P.
collection PubMed
description Intrinsic involvement of bile ducts, by metastatic colorectal adenocarcinoma growing from within or invading the lumen of bile ducts, is not a well recognized pattern of tumor growth. Clinical, radiographic, operative, and histopathologic aspects of 15 patients with intrabiliary colorectal metastases were described. Fourteen patients were explored for possible hepatic resection. Two had jaundice, two radiographic evidence of an intrabiliary filling defect, 10 intraoperative evidence of intrabiliary tumor, and six microscopic evidence of intrabiliariy tumor. Eleven patients underwent hepatic resection. Five of the resected patients developed hepatic recurrence. Four patients were explored for possible repeat resection. One had jaundice, one radiographic evidence of an intrabiliary filling defect, all had intraoperative evidence of intrabiliary tumor, and three microscopic evidence of intrabiliary tumor. Three patients underwent repeat hepatic resection. All patients with preoperative jaundice and radiographic evidence of an intrabiliary filling defect were unresectable. Overall, actuarial five-year survival is 33% for those patients resected versus 0% for those not resected. Intraoperative recognition of intrabiliary tumor at exploration for hepatic resection was more common than clinical, radiographic, or histopathologic recognition. More diligent examination of resected liver tissue by the surgeon and pathologist may increase identification of bile duct involvement and aid in achieving adequate tumor clearance.
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spelling pubmed-24240012008-07-08 Recognition of Intrabiliary Hepatic Metastases From Colorectal Adenocarcinoma Povoski, Stephen P. Klimstra, David S. Brown, Karen T. Schwartz, Lawrence H. Kurtz, Robert C. Jarnagin, William R. Fong, Yuman Blumgart, Leslie H. HPB Surg Research Article Intrinsic involvement of bile ducts, by metastatic colorectal adenocarcinoma growing from within or invading the lumen of bile ducts, is not a well recognized pattern of tumor growth. Clinical, radiographic, operative, and histopathologic aspects of 15 patients with intrabiliary colorectal metastases were described. Fourteen patients were explored for possible hepatic resection. Two had jaundice, two radiographic evidence of an intrabiliary filling defect, 10 intraoperative evidence of intrabiliary tumor, and six microscopic evidence of intrabiliariy tumor. Eleven patients underwent hepatic resection. Five of the resected patients developed hepatic recurrence. Four patients were explored for possible repeat resection. One had jaundice, one radiographic evidence of an intrabiliary filling defect, all had intraoperative evidence of intrabiliary tumor, and three microscopic evidence of intrabiliary tumor. Three patients underwent repeat hepatic resection. All patients with preoperative jaundice and radiographic evidence of an intrabiliary filling defect were unresectable. Overall, actuarial five-year survival is 33% for those patients resected versus 0% for those not resected. Intraoperative recognition of intrabiliary tumor at exploration for hepatic resection was more common than clinical, radiographic, or histopathologic recognition. More diligent examination of resected liver tissue by the surgeon and pathologist may increase identification of bile duct involvement and aid in achieving adequate tumor clearance. Hindawi Publishing Corporation 2000-08 /pmc/articles/PMC2424001/ /pubmed/10977117 http://dx.doi.org/10.1155/2000/17619 Text en Copyright © 2000 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Povoski, Stephen P.
Klimstra, David S.
Brown, Karen T.
Schwartz, Lawrence H.
Kurtz, Robert C.
Jarnagin, William R.
Fong, Yuman
Blumgart, Leslie H.
Recognition of Intrabiliary Hepatic Metastases From Colorectal Adenocarcinoma
title Recognition of Intrabiliary Hepatic Metastases From Colorectal Adenocarcinoma
title_full Recognition of Intrabiliary Hepatic Metastases From Colorectal Adenocarcinoma
title_fullStr Recognition of Intrabiliary Hepatic Metastases From Colorectal Adenocarcinoma
title_full_unstemmed Recognition of Intrabiliary Hepatic Metastases From Colorectal Adenocarcinoma
title_short Recognition of Intrabiliary Hepatic Metastases From Colorectal Adenocarcinoma
title_sort recognition of intrabiliary hepatic metastases from colorectal adenocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424001/
https://www.ncbi.nlm.nih.gov/pubmed/10977117
http://dx.doi.org/10.1155/2000/17619
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