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Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo

Inflammation, trauma or nerve injury trigger low-level activity in C-fibres and may cause long-lasting hyperalgesia. Long-term potentiation (LTP) at synapses of primary afferent C-fibres is considered to underlie some forms of hyperalgesia. In previous studies, high- but not low-frequency conditioni...

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Autores principales: Drdla, Ruth, Sandkühler, Jürgen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424039/
https://www.ncbi.nlm.nih.gov/pubmed/18507818
http://dx.doi.org/10.1186/1744-8069-4-18
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author Drdla, Ruth
Sandkühler, Jürgen
author_facet Drdla, Ruth
Sandkühler, Jürgen
author_sort Drdla, Ruth
collection PubMed
description Inflammation, trauma or nerve injury trigger low-level activity in C-fibres and may cause long-lasting hyperalgesia. Long-term potentiation (LTP) at synapses of primary afferent C-fibres is considered to underlie some forms of hyperalgesia. In previous studies, high- but not low-frequency conditioning stimulation of C-fibres has, however, been used to induce LTP in pain pathways. Recently we could show that also conditioning low-frequency stimulation (LFS) at C-fibre intensity induces LTP in vitro as well as in the intact animal, i.e. with tonic descending inhibition fully active. In the slice preparation, this form of LTP requires a rise in postsynaptic Ca(2+)-concentration and activation of Ca(2+)-dependent signalling pathways. Here, we investigated the signalling mechanisms underlying this novel form of LTP in vivo. We found that the signal transduction pathways causing LFS-induced LTP in vivo include activation of neurokinin 1 and N-methyl-D-aspartate receptors, rise of [Ca(2+)](i )from intracellular stores and via T-type voltage-dependent Ca(2+ )channels, activation of phospholipase C, protein kinase C and Ca(2+)-calmodulin dependent kinase II. These pathways match those leading to hyperalgesia in behaving animals and humans. We thus propose that LTP induced by low-level activity in C-fibres may underlie some forms of hyperalgesia.
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spelling pubmed-24240392008-06-11 Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo Drdla, Ruth Sandkühler, Jürgen Mol Pain Research Inflammation, trauma or nerve injury trigger low-level activity in C-fibres and may cause long-lasting hyperalgesia. Long-term potentiation (LTP) at synapses of primary afferent C-fibres is considered to underlie some forms of hyperalgesia. In previous studies, high- but not low-frequency conditioning stimulation of C-fibres has, however, been used to induce LTP in pain pathways. Recently we could show that also conditioning low-frequency stimulation (LFS) at C-fibre intensity induces LTP in vitro as well as in the intact animal, i.e. with tonic descending inhibition fully active. In the slice preparation, this form of LTP requires a rise in postsynaptic Ca(2+)-concentration and activation of Ca(2+)-dependent signalling pathways. Here, we investigated the signalling mechanisms underlying this novel form of LTP in vivo. We found that the signal transduction pathways causing LFS-induced LTP in vivo include activation of neurokinin 1 and N-methyl-D-aspartate receptors, rise of [Ca(2+)](i )from intracellular stores and via T-type voltage-dependent Ca(2+ )channels, activation of phospholipase C, protein kinase C and Ca(2+)-calmodulin dependent kinase II. These pathways match those leading to hyperalgesia in behaving animals and humans. We thus propose that LTP induced by low-level activity in C-fibres may underlie some forms of hyperalgesia. BioMed Central 2008-05-28 /pmc/articles/PMC2424039/ /pubmed/18507818 http://dx.doi.org/10.1186/1744-8069-4-18 Text en Copyright © 2008 Drdla and Sandkühler; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Drdla, Ruth
Sandkühler, Jürgen
Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
title Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
title_full Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
title_fullStr Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
title_full_unstemmed Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
title_short Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
title_sort long-term potentiation at c-fibre synapses by low-level presynaptic activity in vivo
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424039/
https://www.ncbi.nlm.nih.gov/pubmed/18507818
http://dx.doi.org/10.1186/1744-8069-4-18
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