Genome-Wide Compensatory Changes Accompany Drug- Selected Mutations in the Plasmodium falciparum crt Gene

Mutations in PfCRT (Plasmodium falciparum chloroquine-resistant transporter), particularly the substitution at amino acid position 76, confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels...

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Detalles Bibliográficos
Autores principales: Jiang, Hongying, Patel, Jigar J., Yi, Ming, Mu, Jianbing, Ding, Jinhui, Stephens, Robert, Cooper, Roland A., Ferdig, Michael T., Su, Xin-zhuan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424241/
https://www.ncbi.nlm.nih.gov/pubmed/18575593
http://dx.doi.org/10.1371/journal.pone.0002484

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