Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro*

Small interfering RNA molecules (siRNA) hold great promise to specifically target cytoprotective factors to enhance cancer therapy. Like antisense RNA strategies, however, the use of siRNA is limited because of in vivo instability. As a first step to overcome delivery issues, a series of graft copol...

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Detalles Bibliográficos
Autores principales: Sutton, Damon, Kim, Saejeong, Shuai, Xintao, Leskov, Konstantin, Marques, Joao T, Williams, Bryan RG, Boothman, David A, Gao, Jinming
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2006
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426783/
https://www.ncbi.nlm.nih.gov/pubmed/17722531

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