Chitosan nanoparticles for oral drug and gene delivery

Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral...

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Detalles Bibliográficos
Autores principales: Bowman, Katherine, Leong, Kam W
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426784/
https://www.ncbi.nlm.nih.gov/pubmed/17722528
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author Bowman, Katherine
Leong, Kam W
author_facet Bowman, Katherine
Leong, Kam W
author_sort Bowman, Katherine
collection PubMed
description Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptake and promoting gene expression. This review summarizes some of these findings and highlights the potential of chitosan as a component of oral delivery systems.
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spelling pubmed-24267842008-06-20 Chitosan nanoparticles for oral drug and gene delivery Bowman, Katherine Leong, Kam W Int J Nanomedicine Review Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptake and promoting gene expression. This review summarizes some of these findings and highlights the potential of chitosan as a component of oral delivery systems. Dove Medical Press 2006-06 /pmc/articles/PMC2426784/ /pubmed/17722528 Text en © 2006 Dove Medical Press Limited. All rights reserved
spellingShingle Review
Bowman, Katherine
Leong, Kam W
Chitosan nanoparticles for oral drug and gene delivery
title Chitosan nanoparticles for oral drug and gene delivery
title_full Chitosan nanoparticles for oral drug and gene delivery
title_fullStr Chitosan nanoparticles for oral drug and gene delivery
title_full_unstemmed Chitosan nanoparticles for oral drug and gene delivery
title_short Chitosan nanoparticles for oral drug and gene delivery
title_sort chitosan nanoparticles for oral drug and gene delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426784/
https://www.ncbi.nlm.nih.gov/pubmed/17722528
work_keys_str_mv AT bowmankatherine chitosannanoparticlesfororaldrugandgenedelivery
AT leongkamw chitosannanoparticlesfororaldrugandgenedelivery

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