Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel

The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer’s disease (AD). This study investigated whether the ACE gene insertion–deletion (ID) polymorphism is associated with risk of developing dementia...

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Detalles Bibliográficos
Autores principales: Bowirrat, Abdalla, Cui, Jing, Waraska, Kristin, Friedland, Robert P, Oscar-Berman, Marlene, Farrer, Lindsay A, Korczyn, Amos, Baldwin, Clinton T
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2005
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426814/
https://www.ncbi.nlm.nih.gov/pubmed/18568123
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author Bowirrat, Abdalla
Cui, Jing
Waraska, Kristin
Friedland, Robert P
Oscar-Berman, Marlene
Farrer, Lindsay A
Korczyn, Amos
Baldwin, Clinton T
author_facet Bowirrat, Abdalla
Cui, Jing
Waraska, Kristin
Friedland, Robert P
Oscar-Berman, Marlene
Farrer, Lindsay A
Korczyn, Amos
Baldwin, Clinton T
author_sort Bowirrat, Abdalla
collection PubMed
description The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer’s disease (AD). This study investigated whether the ACE gene insertion–deletion (ID) polymorphism is associated with risk of developing dementia of Alzheimer’s type (DAT) in an Arab–Israeli community, a unique genetic isolate where there is a high prevalence of DAT. In contrast to several other studies, we found no evidence of an association between this polymorphism and either DAT or age-related cognitive decline (ARCD).
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spelling pubmed-24268142008-06-20 Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel Bowirrat, Abdalla Cui, Jing Waraska, Kristin Friedland, Robert P Oscar-Berman, Marlene Farrer, Lindsay A Korczyn, Amos Baldwin, Clinton T Neuropsychiatr Dis Treat Original Research The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer’s disease (AD). This study investigated whether the ACE gene insertion–deletion (ID) polymorphism is associated with risk of developing dementia of Alzheimer’s type (DAT) in an Arab–Israeli community, a unique genetic isolate where there is a high prevalence of DAT. In contrast to several other studies, we found no evidence of an association between this polymorphism and either DAT or age-related cognitive decline (ARCD). Dove Medical Press 2005-03 /pmc/articles/PMC2426814/ /pubmed/18568123 Text en © 2005 Dove Medical Press Limited. All rights reserved
spellingShingle Original Research
Bowirrat, Abdalla
Cui, Jing
Waraska, Kristin
Friedland, Robert P
Oscar-Berman, Marlene
Farrer, Lindsay A
Korczyn, Amos
Baldwin, Clinton T
Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel
title Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel
title_full Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel
title_fullStr Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel
title_full_unstemmed Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel
title_short Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel
title_sort lack of association between angiotensin-converting enzyme and dementia of the alzheimer’s type in an elderly arab population in wadi ara, israel
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426814/
https://www.ncbi.nlm.nih.gov/pubmed/18568123
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