Cargando…

Spatial mapping of splicing factor complexes involved in exon and intron definition

We have analyzed the interaction between serine/arginine-rich (SR) proteins and splicing components that recognize either the 5′ or 3′ splice site. Previously, these interactions have been extensively characterized biochemically and are critical for both intron and exon definition. We use fluorescen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ellis, Jonathan D., Llères, David, Denegri, Marco, Lamond, Angus I., Cáceres, Javier F.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426932/ https://www.ncbi.nlm.nih.gov/pubmed/18559666 http://dx.doi.org/10.1083/jcb.200710051

Ejemplares similares

A unified mechanism for intron and exon definition and back-splicing
por: Li, Xueni, et al.
Publicado: (2019)

The exon junction complex is required for definition and excision of neighboring introns in Drosophila
por: Hayashi, Rippei, et al.
Publicado: (2014)

Evolution of Exon-Intron Structure and Alternative Splicing
por: Koralewski, Tomasz E., et al.
Publicado: (2011)

Global control of aberrant splice-site activation by auxiliary splicing sequences: evidence for a gradient in exon and intron definition
por: Královičová, Jana, et al.
Publicado: (2007)

The Exon Junction Complex and intron removal prevent re-splicing of mRNA
por: Joseph, Brian, et al.
Publicado: (2021)

Splicing Enhancers at Intron–Exon Borders Participate in Acceptor Splice Sites Recognition
por: Kováčová, Tatiana, et al.
Publicado: (2020)

Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing
por: Wongpalee, Somsakul Pop, et al.
Publicado: (2016)

The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons
por: Minovitsky, Simon, et al.
Publicado: (2005)

Splicing of designer exons informs a biophysical model for exon definition
por: Arias, Mauricio A., et al.
Publicado: (2015)

Compensatory relationship between splice sites and exonic splicing signals depending on the length of vertebrate introns
por: Dewey, Colin N, et al.
Publicado: (2006)

Splice site proximity influences alternative exon definition
por: Carranza, Francisco, et al.
Publicado: (2022)

Exon definition as a potential negative force against intron losses in evolution
por: Niu, Deng-Ke
Publicado: (2008)

Defective splicing, disease and therapy: searching for master checkpoints in exon definition
por: Buratti, Emanuele, et al.
Publicado: (2006)

Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays
por: Sugnet, Charles W, et al.
Publicado: (2006)

Biased exon/intron distribution of cryptic and de novo 3′ splice sites
por: Královičová, Jana, et al.
Publicado: (2005)

SRSF2 directly inhibits intron splicing to suppresses cassette exon inclusion
por: Moon, Heegyum, et al.
Publicado: (2017)

Exon definitive regions for MPC1 microexon splicing and its usage for splicing modulation
por: Koh, Eunjin, et al.
Publicado: (2023)

Blocking of an intronic splicing silencer completely rescues IKBKAP exon 20 splicing in familial dysautonomia patient cells
por: Bruun, Gitte H, et al.
Publicado: (2018)

Intronic motif pairs cooperate across exons to promote pre-mRNA splicing
por: Ke, Shengdong, et al.
Publicado: (2010)

DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon–intron structure
por: Gelfman, Sahar, et al.
Publicado: (2013)

Structural disruption of exonic stem–loops immediately upstream of the intron regulates mammalian splicing
por: Saha, Kaushik, et al.
Publicado: (2020)

SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletion
por: Canson, Daffodil M, et al.
Publicado: (2023)

The evolution, impact and properties of exonic splice enhancers
por: Cáceres, Eva Fernández, et al.
Publicado: (2013)

Complex Exon-Intron Marking by Histone Modifications Is Not Determined Solely by Nucleosome Distribution
por: Dhami, Pawandeep, et al.
Publicado: (2010)

Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position
por: Shen, Manli, et al.
Publicado: (2012)

Alternative splicing of a cryptic exon embedded in intron 6 of SMN1 and SMN2
por: Yoshimoto, Satomi, et al.
Publicado: (2016)

Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing
por: Liu, Nan, et al.
Publicado: (2020)

First Identification of Rare Exonic and Deep Intronic Splice-Altering Variants in Patients With Beta-Sarcoglycanopathy
por: Xie, Zhiying, et al.
Publicado: (2022)

Absence of an Intron Splicing Silencer in Porcine Smn1 Intron 7 Confers Immunity to the Exon Skipping Mutation in Human SMN2
por: Doktor, Thomas Koed, et al.
Publicado: (2014)

NMR structure of the 5′ splice site in the group IIB intron Sc.ai5γ—conformational requirements for exon–intron recognition
por: Kruschel, Daniela, et al.
Publicado: (2014)

The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation
por: Rodor, Julie, et al.
Publicado: (2016)

Mapping intron retention events contributing to complex traits using splice quantitative trait locus
por: Wang, Siyuan, et al.
Publicado: (2023)

SR protein-mediated inhibition of CFTR exon 9 inclusion: molecular characterization of the intronic splicing silencer
por: Buratti, Emanuele, et al.
Publicado: (2007)

Exon splicing analysis of intronic variants in multigene cancer panel testing for hereditary breast/ovarian cancer
por: Ryu, Jin‐Sun, et al.
Publicado: (2020)

Isolation and characterization of post-splicing lariat–intron complexes
por: Yoshimoto, Rei, et al.
Publicado: (2009)

Skipping of Exons by Premature Termination of Transcription and Alternative Splicing within Intron-5 of the Sheep SCF Gene: A Novel Splice Variant
por: Saravanaperumal, Siva Arumugam, et al.
Publicado: (2012)

In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles
por: Leung, Anthony K.L., et al.
Publicado: (2002)

Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene
por: Mercado, Pablo Arrisi, et al.
Publicado: (2005)

Alternative splicing and genetic diversity: silencers are more frequently modified by SNVs associated with alternative exon/intron borders
por: de Souza, Jorge E. S., et al.
Publicado: (2011)

Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1
por: Hamdan, Hamdan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_80s22lff5n4na2oj188rugl8o2