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Cell motility through plasma membrane blebbing

Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho–guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this...

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Detalles Bibliográficos
Autores principales: Fackler, Oliver T., Grosse, Robert
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426937/
https://www.ncbi.nlm.nih.gov/pubmed/18541702
http://dx.doi.org/10.1083/jcb.200802081
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author Fackler, Oliver T.
Grosse, Robert
author_facet Fackler, Oliver T.
Grosse, Robert
author_sort Fackler, Oliver T.
collection PubMed
description Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho–guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this paper, we discuss recent evidence in support of a central role of nonapoptotic membrane blebbing for cell migration and cancer cell invasion as well as advances in our understanding of the underlying molecular mechanisms. Based on these studies, we propose that in a physiological context, bleb-associated cell motility reflects a cell's response to reduced substratum adhesion. The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction.
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spelling pubmed-24269372008-12-16 Cell motility through plasma membrane blebbing Fackler, Oliver T. Grosse, Robert J Cell Biol Reviews Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho–guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this paper, we discuss recent evidence in support of a central role of nonapoptotic membrane blebbing for cell migration and cancer cell invasion as well as advances in our understanding of the underlying molecular mechanisms. Based on these studies, we propose that in a physiological context, bleb-associated cell motility reflects a cell's response to reduced substratum adhesion. The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction. The Rockefeller University Press 2008-06-16 /pmc/articles/PMC2426937/ /pubmed/18541702 http://dx.doi.org/10.1083/jcb.200802081 Text en © 2008 Fackler and Grosse This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Fackler, Oliver T.
Grosse, Robert
Cell motility through plasma membrane blebbing
title Cell motility through plasma membrane blebbing
title_full Cell motility through plasma membrane blebbing
title_fullStr Cell motility through plasma membrane blebbing
title_full_unstemmed Cell motility through plasma membrane blebbing
title_short Cell motility through plasma membrane blebbing
title_sort cell motility through plasma membrane blebbing
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426937/
https://www.ncbi.nlm.nih.gov/pubmed/18541702
http://dx.doi.org/10.1083/jcb.200802081
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