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Cell motility through plasma membrane blebbing
Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho–guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426937/ https://www.ncbi.nlm.nih.gov/pubmed/18541702 http://dx.doi.org/10.1083/jcb.200802081 |
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author | Fackler, Oliver T. Grosse, Robert |
author_facet | Fackler, Oliver T. Grosse, Robert |
author_sort | Fackler, Oliver T. |
collection | PubMed |
description | Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho–guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this paper, we discuss recent evidence in support of a central role of nonapoptotic membrane blebbing for cell migration and cancer cell invasion as well as advances in our understanding of the underlying molecular mechanisms. Based on these studies, we propose that in a physiological context, bleb-associated cell motility reflects a cell's response to reduced substratum adhesion. The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction. |
format | Text |
id | pubmed-2426937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-24269372008-12-16 Cell motility through plasma membrane blebbing Fackler, Oliver T. Grosse, Robert J Cell Biol Reviews Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho–guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this paper, we discuss recent evidence in support of a central role of nonapoptotic membrane blebbing for cell migration and cancer cell invasion as well as advances in our understanding of the underlying molecular mechanisms. Based on these studies, we propose that in a physiological context, bleb-associated cell motility reflects a cell's response to reduced substratum adhesion. The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction. The Rockefeller University Press 2008-06-16 /pmc/articles/PMC2426937/ /pubmed/18541702 http://dx.doi.org/10.1083/jcb.200802081 Text en © 2008 Fackler and Grosse This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Fackler, Oliver T. Grosse, Robert Cell motility through plasma membrane blebbing |
title | Cell motility through plasma membrane blebbing |
title_full | Cell motility through plasma membrane blebbing |
title_fullStr | Cell motility through plasma membrane blebbing |
title_full_unstemmed | Cell motility through plasma membrane blebbing |
title_short | Cell motility through plasma membrane blebbing |
title_sort | cell motility through plasma membrane blebbing |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426937/ https://www.ncbi.nlm.nih.gov/pubmed/18541702 http://dx.doi.org/10.1083/jcb.200802081 |
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