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CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Runx2, an essential transactivator for osteoblast differentiation, is tightly regulated at both the transcriptional and posttranslational levels. In this paper, we report that CHIP (C terminus of Hsc70-interacting protein)/STUB1 regulates Runx2 protein stability via a ubiquitination-degradation mech...

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Detalles Bibliográficos
Autores principales:	Li, Xueni, Huang, Mei, Zheng, Huiling, Wang, Yinyin, Ren, Fangli, Shang, Yu, Zhai, Yonggong, Irwin, David M., Shi, Yuguang, Chen, Di, Chang, Zhijie
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426947/ https://www.ncbi.nlm.nih.gov/pubmed/18541707 http://dx.doi.org/10.1083/jcb.200711044

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