Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

The SCF(FBW7) ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers. The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular localizations, suggesting that each has unique functions. We used gene targeting...

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Detalles Bibliográficos
Autores principales: Grim, Jonathan E., Gustafson, Michael P., Hirata, Roli K., Hagar, Amanda C., Swanger, Jherek, Welcker, Markus, Hwang, Harry C., Ericsson, Johan, Russell, David W., Clurman, Bruce E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426948/
https://www.ncbi.nlm.nih.gov/pubmed/18559665
http://dx.doi.org/10.1083/jcb.200802076

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