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Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process
BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a vasocentric process characterized by infiltrates of lymphocytes and eosinophils, usually affecting the muscular arteries of the head and neck. Currently it is unclear whether it is a reactive or neoplastic process. REPORT: We presen...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427016/ https://www.ncbi.nlm.nih.gov/pubmed/18510751 http://dx.doi.org/10.1186/1746-1596-3-22 |
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author | Gonzalez-Cuyar, Luis F Tavora, Fabio Zhao, X Frank Wang, Guanghua Auerbach, Aaron Aguilera, Nadine Burke, Allen P |
author_facet | Gonzalez-Cuyar, Luis F Tavora, Fabio Zhao, X Frank Wang, Guanghua Auerbach, Aaron Aguilera, Nadine Burke, Allen P |
author_sort | Gonzalez-Cuyar, Luis F |
collection | PubMed |
description | BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a vasocentric process characterized by infiltrates of lymphocytes and eosinophils, usually affecting the muscular arteries of the head and neck. Currently it is unclear whether it is a reactive or neoplastic process. REPORT: We present a 61-year-old African American male with a twenty year history of superficial skin patches involving the head and neck region. An excisional biopsy of a right submental lymph node revealed an atypical T-cell lymphocytic process, diagnosed as peripheral T-cell lymphoma after immunophenotyping and molecular studies. Three months later the patient underwent a biopsy of a left temporal nodule that was diagnosed as ALHE. Subsequently, at two year follow-up, the patient was diagnosed with Mycosis Fungoides. Polymerase chain reaction for T cell receptor gamma showed the same T-cell receptor gene rearrangement in both the temporal mass and the right submental lymph node. CONCLUSION: ALHE with molecular evidence of monoclonality is extremely unusual, as is the association with nodal peripheral T-cell nodal lymphoma. The findings of this case support our hypothesis that ALHE might be an early form of T-cell lymphoma. |
format | Text |
id | pubmed-2427016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24270162008-06-13 Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process Gonzalez-Cuyar, Luis F Tavora, Fabio Zhao, X Frank Wang, Guanghua Auerbach, Aaron Aguilera, Nadine Burke, Allen P Diagn Pathol Case Report BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a vasocentric process characterized by infiltrates of lymphocytes and eosinophils, usually affecting the muscular arteries of the head and neck. Currently it is unclear whether it is a reactive or neoplastic process. REPORT: We present a 61-year-old African American male with a twenty year history of superficial skin patches involving the head and neck region. An excisional biopsy of a right submental lymph node revealed an atypical T-cell lymphocytic process, diagnosed as peripheral T-cell lymphoma after immunophenotyping and molecular studies. Three months later the patient underwent a biopsy of a left temporal nodule that was diagnosed as ALHE. Subsequently, at two year follow-up, the patient was diagnosed with Mycosis Fungoides. Polymerase chain reaction for T cell receptor gamma showed the same T-cell receptor gene rearrangement in both the temporal mass and the right submental lymph node. CONCLUSION: ALHE with molecular evidence of monoclonality is extremely unusual, as is the association with nodal peripheral T-cell nodal lymphoma. The findings of this case support our hypothesis that ALHE might be an early form of T-cell lymphoma. BioMed Central 2008-05-29 /pmc/articles/PMC2427016/ /pubmed/18510751 http://dx.doi.org/10.1186/1746-1596-3-22 Text en Copyright © 2008 Gonzalez-Cuyar et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Gonzalez-Cuyar, Luis F Tavora, Fabio Zhao, X Frank Wang, Guanghua Auerbach, Aaron Aguilera, Nadine Burke, Allen P Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process |
title | Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process |
title_full | Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process |
title_fullStr | Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process |
title_full_unstemmed | Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process |
title_short | Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process |
title_sort | angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral t-cell lymphoma: evidence for multicentric t-cell lymphoproliferative process |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427016/ https://www.ncbi.nlm.nih.gov/pubmed/18510751 http://dx.doi.org/10.1186/1746-1596-3-22 |
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